Advertisement

Immunological Monitoring in Remission Acute Myeloid Leukemia During Maintenance Therapy

  • H. J. Pielken
  • D. Urbanitz
  • P. Koch
  • J. v. d. Loo
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 30)

Abstract

In a study beginning in 1981 43 adult patients with acute myeloid leukemia (AML) in remission were treated with cytosine arabinoside (Ara-C) alternately combined with daunorubicin, thioguanine, or cyclophosphamide in maintenance therapy every 4 weeks. 22 of the 43 patients were randomized for chemotherapy (CT) only and 21 for chemo-immunotherapy (CIT). CIT patients received immunotherapy with additional neuraminidase-treated allogeneic viable blasts given between the chemotherapy courses. During maintenance therapy immunologic monitoring was carried out.

Keywords

Acute Myeloid Leukemia Maintenance Therapy Skin Test Acute Myelogenous Leukemia Cytosine Arabinoside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Bates SE, James YS, Tranum BL (1979) Immunological skin testing and interpretation. Cancer 43: 2306–2314PubMedCrossRefGoogle Scholar
  2. 2.
    Bekesy JG, Holland JF, Flemminger F, Yates J, Henderson ES (1977) Immunotherapeutic efficacy of neuraminidase-treated allogeneic myeloblasts in patients with acute myelocytic leukemia. In: Chirigos MA (ed) Control of neoplasia by modulation of the immune system, pp 573–529Google Scholar
  3. 3.
    Rodeck U, Kuwert E, Keinecke H-O (1983) Alters-und geschlechtsabhängige Veränderungen humaner T-Lymphozyten-Subpopulationen. Dtsch Med Wochenschr 108: 1880–1883PubMedCrossRefGoogle Scholar
  4. 4.
    Urbanitz D, Büchner Th, Pielken HJ, van de Loo J (1983) Immunotherapy in the treatment of acute myelogenous leukemia (AML): rationale, results and future prospects. Klin Wochenschr 61: 947–954PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • H. J. Pielken
    • 1
  • D. Urbanitz
    • 1
  • P. Koch
    • 1
  • J. v. d. Loo
    • 1
  1. 1.Medical Clinic, Department of Internal Medicine AUniversity of MunsterMünsterFederal Republic of Germany

Personalised recommendations