Modification of tRNA and Its Applicability for the Assessment of Prognosis, State of Differentiation, and Clonality in Human Leukemias and Lymphomas
The central agents in protein synthesis are tRNA molecules to which amino acids are attached prior to their polymerisation into polypeptides. Besides its role in protein synthesis, tRNA also plays an important role in the regulation of cell metabolism. These regulatory functions involve alterations of tRNA modifications. The modified nucleosides occur at well-defined positions in specific tRNAs (Fig. 1 a).
KeywordsChronic Lymphocytic Leukemia Hairy Cell Leukemia Acute Myeloblastic Leukemia tRNA Molecule Solitary Plasmacytoma
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