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Postinduction and Preremission Chemotherapy Alternatives for Adult AML: Three Multicenter Studies of the AML Cooperative Group

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Book cover Acute Leukemias

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 30))

Abstract

Various intensive induction regimens for adult AML involving a total of 3380 patients produced a median of 60% complete remissions (CR) ranging from 47% to 72% in multicenter [2, 4, 8, 10–12, 14] and major monocenter [5, 6, 9, 13] studies. The probability of continuous CR in these studies ranges from 8% to 45% (median, 24%) at 3 years. Corresponding data projected to 5 years yield a continuous CR rate of 10%–28% (median, 21%). No clear correlation has been found between CR duration and the type of induction or postinduction treatment. In particular, the role of consolidation and long-term maintenance therapy has remained controversial.

Supported by grant BMFT 01 ZP 0123 of the Federal Government.

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Authors and Affiliations

  1. Clinic for Internal Medicine and Poliklinic, University of Münster, Münster, Federal Republic of Germany

    T. Büchner

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  1. T. Büchner
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  2. W. Hiddemann
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  3. D. Urbanitz
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  4. H. Kreutzmann
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  5. G. Maschmeyer
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  6. F. Wendt
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  7. R. Kuse
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  8. A. Mohr
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  9. W. Gassmann
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  10. H. Löffler
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  11. K. Straif
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  12. H. A. Vaupel
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  13. H. J. König
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  14. H. Rühl
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  15. M. R. Nowrousian
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  16. H. G. Fuhr
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  17. G. Zeile
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  18. A. von Paleske
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  19. J. Schwamborn
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  20. H. H. Fülle
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  21. H. Bartels
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  22. B. Emmerich
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  23. E. Lengfelder
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  24. R. Donhuijsen-Ant
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  25. A. Ho
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  26. K. Mainzer
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  27. H. Köppler
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  28. E. Thiel
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  29. G. Middelhoff
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  30. L. Nowicki
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  31. K. H. Zurborn
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  32. W. Siegert
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  33. M. Planker
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  34. W. Augener
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  35. A. Heinecke
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Editor information

Editors and Affiliations

  1. Departments of Internal Medicine and Pediatrics, University of Münster, Albert-Schweitzer-Strasse 33, D-4400, Münster, Federal Republic of Germany

    T. Büchner , G. Schellong , W. Hiddemann , D. Urbanitz  & J. Ritter , , ,  & 

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© 1987 Springer-Verlag Berlin Heidelberg

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Büchner, T. et al. (1987). Postinduction and Preremission Chemotherapy Alternatives for Adult AML: Three Multicenter Studies of the AML Cooperative Group. In: Büchner, T., Schellong, G., Hiddemann, W., Urbanitz, D., Ritter, J. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71213-5_10

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  • DOI: https://doi.org/10.1007/978-3-642-71213-5_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16556-9

  • Online ISBN: 978-3-642-71213-5

  • eBook Packages: Springer Book Archive

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