Abstract
Various intensive induction regimens for adult AML involving a total of 3380 patients produced a median of 60% complete remissions (CR) ranging from 47% to 72% in multicenter [2, 4, 8, 10–12, 14] and major monocenter [5, 6, 9, 13] studies. The probability of continuous CR in these studies ranges from 8% to 45% (median, 24%) at 3 years. Corresponding data projected to 5 years yield a continuous CR rate of 10%–28% (median, 21%). No clear correlation has been found between CR duration and the type of induction or postinduction treatment. In particular, the role of consolidation and long-term maintenance therapy has remained controversial.
Supported by grant BMFT 01 ZP 0123 of the Federal Government.
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Bennett JM, Catovsky D, Daniel MTh, Flandrin G, Galton DAG, Gralnick HR, Sultan CO (1976) Proposals for the classification of the acute leukemias. Br J Haematol 33: 451
Büchner Th, Urbanitz D, Hiddemann W, Rühl H, Ludwig WD, Fischer J, Aul HC, Vaupel HA, Kuse R, Zeile G, Nowrousuan MR, König HJ, Walter M, Wendt FC, Sodo-mann H, Hossfeld DK, von Paleske A, Löffler H, Gassmann W, Hellriegel KP, Fülle HH, Lunscken Ch, Emmerich B, Pralle H, Pees HW, Pfreundschuh M, Bartels H, Koeppen KM, Schwerdtfeger R, Donhuijsen-Ant R, Mainzer K, Bonfert B, Köppler H, Zur-born KH, Ranft K, Thiel E, Heinecke A (1985) Intensified induction and consolidation with or without maintenance chemotherapy for acute myeloid leukemia (AML): Two multicenter studies of the German AML Cooperative Group. J Clin Oncol 3: 1583
Büchner Th, Urbanitz D, Rühl H, Fischer J, Kuse R for the AML Cooperative Group (1985) Role of chemotherapy for AML in remission. Lancet I: 1224
Cassileth PA, Begg CB, Bennett JM, Bozdech M, Benham Kahn S, Weiler C, Glick JH (1984) A randomized study of the efficacy of consolidation therapy in adult acute non-lymphocytic leukemia. Blood 63: 843
Champlin R, Jacobs A, Gale RP, et al. (1984) Prolonged survival in acute myelogenous leukemia without maintenance chemotherapy. Lancet I: 894–896
Clarkson B, Gee T, Arlin Z, et a1. (1984) Current status of treatment of acute leukemia in adults: an overview. In: Büchner Th, Urbanitz D, van de Loo J (eds) Therapie der Akuten Leukämien — Therapy of Acute Leukemias. Springer, Berlin Heidelberg New York Tokyo, pp 1–32
Gale RP, Cline MJ for the UCLA Acute Leukemia Study Group (1977) High remission-induction rate in acute myeloid leukemia. Lancet 1: 497–499
Glucksberg H, Cheever MA, Farewell VT, et al. (1981) High-dose combination chemotherapy for acute nonlymphoblastic leukemia in adults. Cancer 48: 1073–1081
Keating MH, Smith TL, McCredie KB, et al. (1981) A four-year experience with anthracy-cline, cytosine arabinoside, vincristine and prednisone combination chemotherapy in 325 adults with acute leukemia. Cancer 47: 2779–2788
Rai KR, Holland JF. Glidewell OJ, et al. (1981) Treatment of acute myelocytic leukemia: a study by cancer and leukemia Group B. Blood 58:1203–1212
Sauter Chr, Fopp M, Imbach P, et al. (1984) Acute myelogenous leukaemia: Maintenance chemotherapy after early consolidation treatment does not prolong survival. Lancet 1.379–382
Vogler WR, Winton EF, Fordon DS, et al. (1984) A randomized comparison of postremission therapy in acute myelogenous leukemia: a southeast Cancer Study Group trial. Blood 63: 1039–1045
Weinstein HJ, Mayer RJ, Rosenthal DS, et al. (1983) Chemotherapy for acute myelogenous leukemia in children and adults: VAPA update. Blood 62: 315–319
Yates J, Glidewell O, Wiernik P, et al. (1982) Cytosine arabinoside with daunorubicin or adriamycin for therapy of acute myelocytic leukemia: CALGB study. Blood 60: 454–462
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© 1987 Springer-Verlag Berlin Heidelberg
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Büchner, T. et al. (1987). Postinduction and Preremission Chemotherapy Alternatives for Adult AML: Three Multicenter Studies of the AML Cooperative Group. In: Büchner, T., Schellong, G., Hiddemann, W., Urbanitz, D., Ritter, J. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71213-5_10
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DOI: https://doi.org/10.1007/978-3-642-71213-5_10
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