125I Embolotheraphy of Renal Tumors

  • E. K. Lang


Radical nephrectomy is the procedure of choice for management of (Robson) stage 1 and 2 renal cell carcinomas (Table 1) [1–3]. Expanded surgical procedures have made possible the attack and successful removal of tumor extensions into the inferior vena cava and even into the right atrium and ventricle [4–8]. The 5-year survival rate for stage 1 and 2 renal cell carcinomas managed by radical nephrectomy has been reported as 67% and 51% respectively [3]. Even in patients with tumor extension into the inferior vena cava, the infrahepatic segment of the inferior vena cava, or the right atrium, 30–40 percentile 5-year survival rates are reported for surgical procedures extirpating the primary lesion and intravascular tumor extension [6–8].


Renal Cell Carcinoma Metastatic Renal Cell Carcinoma Radical Nephrectomy Skeletal Metastasis Transcatheter Embolization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Robson CJ, Churchill BM, Anderson W (1969) The results of radical nephrectomy for renal cell carcinoma. J Urol 101: 297–301PubMedGoogle Scholar
  2. 2.
    Freed SZ, Feldman JA, Srayragen S (1977) Follow up of patients after nephrectomy for renal cell carcinoma. Urology 9: 500–503PubMedCrossRefGoogle Scholar
  3. 3.
    McNichols DW, Segura JW, DeWeerd JH (1981) Renal cell carcinoma: long term survival and late recurrence. J Urol 126: 17–23PubMedGoogle Scholar
  4. 4.
    Kearney GP, Waters WB, Klein LA, Richie JP, Gittes RF (1981) Results of inferior vena cava resection for renal cell carcinoma. J Urol 125: 769–773PubMedGoogle Scholar
  5. 5.
    Cummings JB, Li W, Ryan JA, Horton WG, Paton RR (1979) Operative management of renal cell carcinoma with supradiaphragmatic caval extension. J Urol 122: 829–832PubMedGoogle Scholar
  6. 6.
    Waters WB, Richie JP (1979) Aggressive surgical approach to renal cell carcinoma: review of 130 cases. J Urol 122: 306–309PubMedGoogle Scholar
  7. 7.
    Novick AC, Cosgrove DM (1980) Surgical approach for removal of renal cell carcinoma extending into the vena cava and the right atrium. J Urol 123: 947–950PubMedGoogle Scholar
  8. 8.
    Skinner DG, Pfister RF, Colvin R (1972) Extension of renal cell carcinoma into the vena cava: the rationale for aggressive surgical management. J Urol 107: 711–716PubMedGoogle Scholar
  9. 9.
    Giuliani L, Martorana G, Giberti C, Pescatore D, Magnani G (1983) Results of radical nephrectomy with extensive lymphadenectomy for renal cell carcinoma. J Urol 130: 664–668PubMedGoogle Scholar
  10. 10.
    Peters PC, Brown GL (1980) The role of lymphadenectomy in the management of renal cell carcinoma. Urol Clin North Am 7: 705–709PubMedGoogle Scholar
  11. 11.
    O’Dea MJ, Zincke H, Utz DC, Bernatz PE (1978) The treatment of renal cell carcinoma with solitary metastasis. J Urol 120: 540–542PubMedGoogle Scholar
  12. 12.
    Fuselier HA, Guice SL, Brannan W, Ochsner MG, Sangisetty KV, Beckman EN, Barnes CA (1983) Renal cell carcinoma. The Ochsner Medical Institution experience (1945–1978). J Urol 130: 445–448PubMedGoogle Scholar
  13. 13.
    DeKernion JB, Ramming KP, Smith RB (1978) The natural history of metastatic renal cell carcinoma: a computer analysis. J Urol 120: 148–152PubMedGoogle Scholar
  14. 14.
    Middleton RG (1967) Surgery for metastatic renal cell carcinoma. J Urol 97: 973–977PubMedGoogle Scholar
  15. 15.
    Barney JD, Churchill EJ (1939) Adenocarcinoma of the kidney with metastasis to the lung: cured by nephrectomy and lobectomy. J Urol 42: 269–276Google Scholar
  16. 15a.
    Hrushesky WJ, Murphy JP (1977) Current status of therapy of advanced renal carcinoma. J Surg Oncol 9: 277–288PubMedCrossRefGoogle Scholar
  17. 16.
    DeKernion JB (1983) Treatment of advanced renal cell carcinoma-Traditional methods and innovative approaches. J Urol 130: 2–7PubMedGoogle Scholar
  18. 17.
    Nemoto R, Kato T, Iwata K, et al. (1930) Evaluation of therapeutic arterial embolization in renal cell carcinoma using microencapsulated mytomycin-c. Urology 17: 315–319CrossRefGoogle Scholar
  19. 18.
    Neidhart JA, Murphy SG, Hennick LA, Wise AJ (1980) Active specific immunotherapy of stage IV renal cell carcinoma with aggregated tumor antigen adjuvant. Cancer 46: 1128–1134PubMedCrossRefGoogle Scholar
  20. 19.
    Montie JE, Bukowski RM, James RE, Straffm RA, Stewart BH (1982) A critical review of immunotherapy of disseminated renal adenocarcinoma. J Surg Oncol 21: 5–8PubMedCrossRefGoogle Scholar
  21. 19a.
    DeKernion JB, Sarna G, Figlin R, Lindner A, Smith RB (1983) The treatment of renal cell carcinoma with human leukocyte alpha-interferon. J Urol 130: 1063–1066PubMedGoogle Scholar
  22. 20.
    Quesada JR, Swanson DA, Trindade A, Gutterman JU (1983) Renal cell carcinoma antitumor effective leukocyte interferon. Cancer Res 43: 940–947PubMedGoogle Scholar
  23. 21.
    DeKernion JB, Ramming KP (1980) The therapy of renal adenocarcinoma with immune RNA. Invest Urol 17: 378–381PubMedGoogle Scholar
  24. 22.
    Morales A, Kiruluta G, Lott S (1975) Hormones in treatment of metastatic renal cancer. J Urol 114: 692–693PubMedGoogle Scholar
  25. 23.
    Pierson J, Friedman MA, Hoffman DJ Jr (1981) Hormone receptor in renal cell carcinoma: their utility as predictors of response to endocrine therapy. Cancer Chemother Pharmacol 6: 151Google Scholar
  26. 24.
    Nakno E, Tada Y, Fujioka H, Matsuda M, Osafune M, Kotake T, Sato B, Takaha M, Sonoda T (1984) Hormone receptor in renal cell carcinoma and correlation with clinical response to endocrine therapy. J Urol 132: 240–245Google Scholar
  27. 25.
    Satomi Y, Takai S, Kondo I, Fukshima S, Furuhata A (1982) Postoperative prophylactic use of progesterone in renal cell carcinoma. J Urol 128: 919–922PubMedGoogle Scholar
  28. 26.
    Arkell DJ, Cotter KP, Fitz-Patrick JD, Shaw RE (1978) Preoperative arterial embolisation of renal carcinoma. Br J Urol 50: 469–473PubMedCrossRefGoogle Scholar
  29. 27.
    Wallace S, Chuang VP, Swanson D, Bracken B, Hersh EM, Ayala A, Johnson D (1981) Embolization of renal carcinoma: experience with 100 patients. Radiology 138: 563–570PubMedGoogle Scholar
  30. 28.
    Weigel JW, Mebost WK, Forat JD, Nobel MJ, Voptka T, Krishnan EC, Jewell WR (1985) Treatment of renal cell carcinoma with renal infarction delayed nephrectomy, medroxyprogesterone and xenogeneic immune RNA. Urology 25: 103–105PubMedCrossRefGoogle Scholar
  31. 29.
    Swanson DE, Johnson DE, Von Eschenbach AC, Chuang VP, Wallace S (1983) Angioinfarction plus nephrectomy for metastatic renal cell carcinoma - an update. J Urol 130: 449–452PubMedGoogle Scholar
  32. 30.
    Gottesman JE, Crawford ED, Grossman HB, Scardino P, McCrecken JD (1985) Infarction - nephrectomy of metastatic renal cell carcinoma. Urology 25: 248–250PubMedCrossRefGoogle Scholar
  33. 31.
    Lang EK (1970) Superselective arterial catheterization of tumors of the urogenital tract: a modality used for perfusion with chemotherapeutic agents and infarction with radioactive pellets. J Urol 104: 16–25PubMedGoogle Scholar
  34. 32.
    Lang EK (1971) Superselective arterial catheterization as a vehicle for delivering radioactive infarct particles to tumors. Radiology 98: 391–399PubMedGoogle Scholar
  35. 33.
    Lang EK (1975) Local regional treatment of neoplasm by radioactive infarct particles introduced by arterial catheterization. Panminerva Med 17: 398–404PubMedGoogle Scholar
  36. 34.
    Lang EK, DeKernion JB (1981) Transcatheter embolization of advanced renal cell carcinoma with radioactive seeds. J Urol 126: 581–586PubMedGoogle Scholar
  37. 35.
    Lang EK, Sullivan F, DeKernion JB (1983) Work in progress: transcatheter embolization of renal cell carcinoma with radioactive infarct particles. Radiology 147: 413–418PubMedGoogle Scholar
  38. 36.
    Lang EK (1982) Advanced renal cell carcinoma treatment by transcatheter embolization with inert material and radioactive particles. In: Ariel JM (ed) Prog Clin Cancer 8: 299–310. Grune + Stratton, NYGoogle Scholar
  39. 37.
    Lang EK (1984) Transcatheter embolization of renal cell carcinoma. In: Lang EK (ed) Current concepts of uroradiology, Chapter 12. Williams and Wilkins, BaltimoreGoogle Scholar
  40. 38.
    Prager MD, Baechtel FS, Peters PC, Brown GL, Greene CL (1981) Specific immunotherapy of human metastatic renal cell carcinoma. In: Proceedings American association of cancer research. Am Assoc Clin Oncol 22: 163 (abstract 647)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • E. K. Lang

There are no affiliations available

Personalised recommendations