T-Cell Reactivity to Polymorphic MHC Determinants II. Self-reactive and Self-restricted T Cells

  • K. Heeg
  • D. Kabelitz
  • H. Wagner
  • J. Reimann
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 126)


The clonal selection approach is simple and direct: “(1) It is necessary for survival that neither immunocytes nor antibodies should exist in the body which are reactive to more than a minimal degree with any accessible body component. (2) Since immune pattern is generated by a random process, a mechanism must exist by which any ‘self-reactive’ cells which may emerge can be eliminated or functionally inhibited. More than one mechanism may be needed to establish and maintain this intrinsic immunological tolerance toward self components” (BURNET 1972). Failure of this censorship mechanism to eliminate a “forbidden” self-reactive lymphocyte clone is autoimmune disease.


Mixed Lymphocyte Reaction Mixed Leukocyte Reaction Tolerant Mouse Autologous Mixed Lymphocyte Reaction Receptor Phenotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • K. Heeg
    • 1
  • D. Kabelitz
    • 1
  • H. Wagner
    • 1
  • J. Reimann
    • 1
  1. 1.Department of Medical Microbiology and ImmunologyUniversity of UlmUlmGermany

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