Human T Cell Clones, Tolerance, and the Analysis of Autoimmunity

  • M. Feldmann
  • J. R. Lamb
  • M. Londei
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 126)

Abstract

A vast number of diseases previously considered to be of ‘unknown aetiology’ are now understood to be due to the pathogenic effects of autoimmunity (reviewed in Smith and Steinberg 1983). Owing to the pivotal role of T cells in the induction of immune responses, we have been interested in the T cells which are present and activated at sites of autoimmune reactions. As thyroid tissue is not infrequently removed at operation from patients with Graves’ disease (autoimmune hyperthyroidism), we have been able to study the lymphoid cells which are activated in vivo, express IL2 receptors, and so can be cloned. These represent an image of the disease process as it occurs in vivo (Londei et al. 1985).

Keywords

Arthritis Influenza Tuberculosis Collagenase Hyperthyroidism 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • M. Feldmann
    • 1
  • J. R. Lamb
    • 1
  • M. Londei
    • 1
  1. 1.ICRF Tumour Immunology Unit, Zoology DepartmentUniversity College LondonLondonUK

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