Development of T Lymphocytes Within the Thymus and Within Thymic Nurse Cells

  • K. Shortman
  • R. Scollay
  • P. Andrews
  • R. Boyd
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 126)


Any detailed study of T-cell development within the thymus requires, as a first step, the ability of distinguish the subpopulations of lymphoid cells which may be steps along a developmental pathway. About 95% of adult murine thymic lymphocytes can be assigned to one of four discrete subpopulations as summarized in Table 1. These major subpopulations, and many of their surface markers, have been recognized for some time, and the recent application of multiparameter flow cytometric analysis (Scollay and Shortman 1983) has merely served to emphasize how clear cut this four-way division can be. This subdivision is obtained as follows.


Nurse Cell Medullary Cell Mouse Thymus Murine Thymocyte Cortical Thymocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • K. Shortman
    • 1
  • R. Scollay
    • 1
  • P. Andrews
    • 1
  • R. Boyd
    • 2
  1. 1.Royal Melbourne HospitalWalter and Eliza Hall Institute of Medical Research, Post OfficeAustralia
  2. 2.Department of Pathology and ImmunologyMonash University Medical SchoolMelbourneAustralia

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