Development of T Lymphocytes Within the Thymus and Within Thymic Nurse Cells
Any detailed study of T-cell development within the thymus requires, as a first step, the ability of distinguish the subpopulations of lymphoid cells which may be steps along a developmental pathway. About 95% of adult murine thymic lymphocytes can be assigned to one of four discrete subpopulations as summarized in Table 1. These major subpopulations, and many of their surface markers, have been recognized for some time, and the recent application of multiparameter flow cytometric analysis (Scollay and Shortman 1983) has merely served to emphasize how clear cut this four-way division can be. This subdivision is obtained as follows.
KeywordsNurse Cell Medullary Cell Mouse Thymus Murine Thymocyte Cortical Thymocyte
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