Regulation of Lytic Function by Recombinant IL2 and Antigen
The study of signals involved in the generation and maintenance of cytotoxic T lymphocytes (CTLs) has been facilitated by the availability of various techniques based on the mixed leukocyte culture (MLC) test (Bain et al. 1964; Bach and Hirschhorn 1964). In addition to the proliferative response in an MLC, CTLs are generated (Hayry and Defendi 1970; Hodes and Svedmyr 1970; Solliday and Bach 1970).
KeywordsTissue Culture Medium Lymphoblastoid Cell Line Lytic Function Mixed Leukocyte Culture Stimulator Ratio
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- Ochoa AC, Wee SL, Bach FH (1985) Loss and re-acquisition of lytic function by cloned cytotoxic T lymphocytes: role of specific antigen and interleukin 2 (IL2). (submitted for publication)Google Scholar
- Ohta N, Anichini A, Reinsmoen NL, Strassmann G, Wernet P, Bach FH (1985) Analysis of human class II antigens by cloned cytolytic T cell reagents: antibodies detecting the HLA-DP produces). Hum Immunol (in press)Google Scholar
- Widmer MB, Clinchy B (1984) Independent regulation of cytolysis and proliferation in antigen- driven CTL clones. J Cell Biochem 8A: 111Google Scholar