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The Influence of HLA Class II Antibodies on HTLV-III (“AIDS”) Antibody ELISA Results

  • P. Kühnl
  • S. Seidl
  • G. Holzberger
Conference paper
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 1)

Abstract

Epidemiological data suggest, that the human T-cell-lymphotropic virus (HTLV-III) ist the causative agent of the acquired immune deficiency syndrome (AIDS). Based on virus antigen preparations of the infected leukemic H9 cell line, commercial HTLV-III ELISA tests have become available a few months ago. Screening for HTLV-III antibodies at every blood donation will probably become mandatory in the Federal Republic of Germany (FRG) after October 1, 1985 and is already now performed routinely in some blood banks. The number of reported AIDS cases is rapidly increasing in many European countries; with a rate of 6.6 per million population, Denmark and Belgium are the two countries with the highest rates (Table 1, MMWR 34/11, 147–150, 1985, CDC, Atlanta, USA).

Keywords

Acquire Immune Deficiency Syndrome Confirmatory Test Plasma Protein Fraction Collaborative Transplant Study Acquire Immune Deficiency Syndrome Case 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Update: Acquired Immunodeficiency Syndrome- Europe, MMWR 34 /11, 147–150, 1985Google Scholar
  2. 2.
    P. Kühnl, S. Seidl, G. Holzberger: HLA DR-antibodies cause positive HTLV-III antibody ELISA results. Lancet i, 1222–1223 (1985)CrossRefGoogle Scholar
  3. 3.
    S. Seidl, P. Kühnl: HTLV-III antibody screening in German blood donors. Lancet i, 1047 (1985)CrossRefGoogle Scholar
  4. 4.
    P. Kühnl et al.: Human T-cell lymphotropic virus antibody screening:Data survey on 33.603 German blood donors correlated to confirmatory tests. Vox Sang. 1985.Google Scholar
  5. 5.
    F.H.J. Claas, G.-J.v. Steenbrugge: Expression of HLA-like structures on a permanent human tumor line PC-93. Tissue Antigens 21, 227–232 (1983)PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • P. Kühnl
    • 1
  • S. Seidl
    • 1
  • G. Holzberger
    • 1
  1. 1.Institute of ImmunohematologyUniversity FrankfurtFrankfurt/MainGermany

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