Incompatible Mother-Child Pairs Found in the PGM1 System.

  • Gunilla Wetterling
Conference paper
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 1)


Since Spencer et al. (1964) demonstrated polymorphism within human red cell phosphoglucomutase incompatible mother-child pairs have been reported. When Bark et al. (1976) succeeded in subtyping PGM1 this deviation from the rules of inheritance also appeared within the Subgroups revealing incompatible homozygosity (Prokop et al. 1981 and Polesky et al. 1983) as well as incompatible heterozygosity (Martin, 1981).


Rare Allele Type A3a2 Silent Allele Incompatible Pair Agar Overlay Method 
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  1. Bark, J.E.; Harris, M.J.; Firth, M.: Typing of the common phosphoglucomutase variants using isoelectric focusing-a new interpretation of the phosphoglucomutase system. J. forensic Sci. Soc. 16: 115–120 (1976).PubMedCrossRefGoogle Scholar
  2. Kühnl, P.; Schmidtmann, U.; Spielmann, W.: Evidence for two additional common alleles at the PGM locus (phosphoglucomutase-EC A comparison by three different techniques. Hum. Genet. 35: 219–223 (1977).PubMedCrossRefGoogle Scholar
  3. Martin, W.: Red cell enzyme groups in paternity testing. Lectures 9th International Congress of the Society for Forensic Haemogenetics, Bern, p.p. 221–239 (1981).Google Scholar
  4. Polesky, H.F.; Sourada, J.M.; Dykes, D.D.: The frequency of null genes calculated from trios in disputed parentage cases. Lectures 10th International Congress of the Society for Forensic Haemogenetics, München, p.p. 161–166 (1983).Google Scholar
  5. Prokop, O.; Radam, G.; Strauch, H.; Rackwitz, A.: Ratio of incompatible homozygosity in mother/child combinations in human enzyme systems. Ärztl. Lab. 27: 221 (1981).Google Scholar
  6. Spencer, N.; Hopkinson, D.A.; Harris, H.: Phosphoglucomutase polymorphism in man. Nature, Lond. 204: 742–745 (1964).CrossRefGoogle Scholar
  7. Sutton, J.G.; Burgess, R.: Genetic evidence for four common alleles at the phosphoglucomutase locus (PGM1) detectable by isoelectric focusing. Vox Sang. 34: 97–103 (1978).PubMedCrossRefGoogle Scholar
  8. Svensson, M.; Wetterling, G.: Identification of PGM1 (phosphoglucomutase EC by isoelectric focusing in a Swedish population. Hum. Hered. 32: 357–361 (1982).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Gunilla Wetterling
    • 1
  1. 1.State Institute for Blood Group SerologySRL, RegionsjukhusetLinköpingSweden

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