PI M5: An Additional Alpha-1-Antitrypsin PI M Subtype Revealed by IEF with Immobilized Ph Gradients

  • S. Weidinger
  • F. Schwarzfischer
Conference paper
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 1)

Abstract

Alpha-1-antitrypsin (α1AT) is an important protease inhibitor (PI) capable of inhibiting a wide variety of serine proteases. Since the first description of genetic variation in 1963 (1) more than 60 genetic variants of this protease inhibitor have been observed (2). For classification of PI variants isoelectric focusing (IEF) has been employed since ten years. IEF has been particularly useful in identifying subtypes of the most common variant PI M (3–9).

Keywords

Electrophoresis Serine Polyacrylamide 

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References

  1. 1.
    Laurell CB, Eriksson S (1963) Scand J Clin Lab Invest 15: 132–140Google Scholar
  2. 2.
    Arnaud P, Allen RC (1981) Electrophoresis ‘81, Walter de Gruyter, Berlin 1981, pp 495–504Google Scholar
  3. 3.
    Klasen EC, Franken C, Volkers WS, Bernini LF (1977) Hum Genet 37: 303–313PubMedCrossRefGoogle Scholar
  4. 4.
    Genz T, Martin JP, Cleve H (1977) Hum Genet 38: 325–332PubMedCrossRefGoogle Scholar
  5. 5.
    Frants RR, Eriksson AW (1978) Hum Hered 28: 201–209PubMedCrossRefGoogle Scholar
  6. 6.
    Weidinger S, Schwarzfischer F, Cleve H (1980) Z Rechtsmed 86: 1–7PubMedCrossRefGoogle Scholar
  7. 7.
    Cox DW, Johnson AM, Fagerhol MK (1980) Hum Genet 53: 429–433PubMedCrossRefGoogle Scholar
  8. 8.
    Constans J, Viau M, Gouaillard C (1980) Hum Genet 55: 119–121PubMedCrossRefGoogle Scholar
  9. 9.
    Weidinger S, Cleve H, Patutschnick W (1982) Z Rechtsmed 88: 203–211PubMedCrossRefGoogle Scholar
  10. 10.
    Bjellgvist B, Ek K, Righetti PG, Gianazza E, Görg A, WestermeierR, Postel W (1982) J Biochem Biophys Methods 6: 317–339CrossRefGoogle Scholar
  11. 11.
    Weidinger S, Cleve H (1984) Electrophoresis 5: 223–226CrossRefGoogle Scholar
  12. 12.
    Weidinger S, Jahn W, Cujnik F, Schwaezfischer F (1985) Hun Genet (in press)Google Scholar
  13. 13.
    Fagerhol MK, Cox DW (1981) Adv Hum Genet 11: 1–62PubMedGoogle Scholar
  14. 14.
    Görg A, Postel W, Weser J, Weidinger S, Patutschnick W, Cleve H (1983) Electrophoresis 4: 153–157CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • S. Weidinger
    • 1
  • F. Schwarzfischer
    • 1
  1. 1.Institute of Anthropology and Human GeneticsUniversity of MunichMünchen 2Federal Republic of Germany

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