PI M5: An Additional Alpha-1-Antitrypsin PI M Subtype Revealed by IEF with Immobilized Ph Gradients
Alpha-1-antitrypsin (α1AT) is an important protease inhibitor (PI) capable of inhibiting a wide variety of serine proteases. Since the first description of genetic variation in 1963 (1) more than 60 genetic variants of this protease inhibitor have been observed (2). For classification of PI variants isoelectric focusing (IEF) has been employed since ten years. IEF has been particularly useful in identifying subtypes of the most common variant PI M (3–9).
KeywordsProtease Inhibitor Blood Group System Type M1M5 Protease Inhibitor Type Fresh Seron
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