PI M5: An Additional Alpha-1-Antitrypsin PI M Subtype Revealed by IEF with Immobilized Ph Gradients

  • S. Weidinger
  • F. Schwarzfischer
Conference paper
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 1)


Alpha-1-antitrypsin (α1AT) is an important protease inhibitor (PI) capable of inhibiting a wide variety of serine proteases. Since the first description of genetic variation in 1963 (1) more than 60 genetic variants of this protease inhibitor have been observed (2). For classification of PI variants isoelectric focusing (IEF) has been employed since ten years. IEF has been particularly useful in identifying subtypes of the most common variant PI M (3–9).


Protease Inhibitor Blood Group System Type M1M5 Protease Inhibitor Type Fresh Seron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • S. Weidinger
    • 1
  • F. Schwarzfischer
    • 1
  1. 1.Institute of Anthropology and Human GeneticsUniversity of MunichMünchen 2Federal Republic of Germany

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