Abstract
The introduction of hybridoma technology [3] has opened a new era in immunological approaches to gastrointestinal malignancies. By means of monoclonal antibodies (MAbs), which represent immunoreagents of defined specificity and affinity, new tumor-associated antigens of the gastrointestinal (GI) tract have been identified and characterized. Moreover, monoclonal antibodies to GI tract cancer associated antigens have been used in diagnostic and as yet preliminary therapeutic clinical applications.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Dippold WG, Lloyd KO, Li LTC, Ikeda HB, Oettgen HF, Old LJ (1980) Cell surface antigens of human malignant melanoma definition of six antigen systems with mouse monoclonal antibodies. Proc Natl Acad Sci USA 77: 6114–6118
Klapdor R, Lehmann U, Bahlo M, Greten H, v Ackeren H, Dallek M, Schreiber HW (1983) CA 19-9 in der Diagnostik und Differential diagnostik des exkretorischen Pankreaskarzinoms. Tumor Diagn Ther 4: 197–201
Köhler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256: 495–497
Koprowski H, Steplewski Z, Mitchell K, Herlyn M, Herlyn D, Fuhrer P (1979) Colorectal carcinoma antigens detected by hybridoma antibodies. Somatic Cell Genet 5: 957–972
Magnani JL, Brockhaus M, Smith DF, Ginsburg V, Blaszezyk M, Mitchell KF, Steplewski Z, Koprowski H (1981) A monosialoganglioside is a monoclonal antibody-defined antigen of colon carcinoma. Science 212: 55–56
Magnani JL, Steplewski Z, Koprowski H, Ginsburg V (1983) Identification of the gastrointestinal and pancreatic cancer associated antigen detected by monoclonal antibody CA 19-9 in sera of patients as a mucin. Cancer Res 43: 5489–5492
Mazauric T, Mitchell K F, Letchworth GJ, Koprowski H, Steplewski Z (1982) Monoclonal antibody defined human lung cell surface protein antigens. Cancer Res 42: 150–154
Saxton RE, Mann BD, Ine RF, Morton DL, Burk M (1982) Monoclonal antibodies to human melanoma identification of two unique proteins on the tumor cell membrane. Proc Am Assoc Cancer Res 23: 362
Schmiegel WH, Kalthoff H, Kreiker C (1984) CA 19-9 bearing mucins-physiological pancreatic secretion products with specific endocrine-paracrine release in pancreatic cancer. Dig Dis Sci 29 /10: 967
Schmiegel WH, Kalthoff H, Arndt R, Gieseking J, Greten H, Klöppel G, Kreiker C, Ladak Lampe V, Ulrich S (1985) Monoclonal antibody-defined human pancreatic cancer-associated antigens. Cancer Res 45: 1402–1407
Schmiegel WH, Kreiker C, Eberl W, Arndt R, Classen M, Greten H, Jessen K, Kalthoff H, Soehendra N, Thiele HG (1985) Monoclonal antibody defines CA 19-9 in pancreatic juices and sera. Gut 26: 456–460
Staab HJ, Hornung A, Anderer FA, Kieninger G (1984) Klinische Bedeutung des zirkulierenden tumorassoziierten Antigens CA 19-9 bei Karzinomen des Verdauungstrakts. Dtsch Med Wochenschr 109: 1141–1147
Ueda R, Ogata S, Morrisey DM, Finstad CC, Szkudiarek J, Whitmore WF, Oettgen HF, Lloyd KO, Old LJ (1981) Cell surface antigens of human renal cancer defined by mouse monoclonal antibodies identification of tissue specific glycoproteins. Proc Natl Acad Sci USA 76: 5122–5126
Villano BC, Brennan S, Brock P, Bucher C, Lun V, McClure M, Rake B, Space S, Westrick B, Schoemaker H, Zurawski V (1983) Radioimmunometric assay for a monoclonal antibody-defined tumor marker CA 19-9. Clin Chem 29 /3: 549–552
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Schmiegel, WH. (1986). Monoclonal Antibodies in Pancreatic Cancer: New Developments. In: Malfertheiner, P., Ditschuneit, H. (eds) Diagnostic Procedures in Pancreatic Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71128-2_46
Download citation
DOI: https://doi.org/10.1007/978-3-642-71128-2_46
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71130-5
Online ISBN: 978-3-642-71128-2
eBook Packages: Springer Book Archive