Critical Evaluation of Basic Mechanisms of Primary Hypertension

  • K. G. Hofbauer
  • G. Bönner
Conference paper


The round-table discussion was held to evaluate critically the significance of the pathogenetic mechanisms presented during the preceding session. It afforded opportunity to identify areas of consensus or controversy and reflected the progress of current research in hypertension. The fact emerged clearly from the discussion that an understanding of the basic mechansims of cardiovascular control and of the patho-genesis of hypertension is important for the rational application of the available anti-hypertensive therapies and for the design of new modes of treatment. The following summary covers the main topics dealt with during the last six contributions and the new aspects arising at the round table.


Essential Hypertension Atrial Natriuretic Peptide Renal Blood Flow Atrial Natriuretic Factor Primary Hypertension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Cruise JL, Houck KA, Michalopoulos GK (1985) Induction of DNA synthesis in cultured rat hepatocytes through stimulation of aradrenoceptor by norepinephrine. Science 227: 749–751PubMedCrossRefGoogle Scholar
  2. 2.
    Regoli D, Barabe J (1980) Pharmacology of bradykinin and related kinins. Pharmacol Rev 32: 1–46PubMedGoogle Scholar
  3. 3.
    Needleman P, Adams SP, Cole BR, Currie MG, Geller DM, Michener RL, Saper CB, Schwartz D, Standaert DG (1985) Atriopeptins as cardiac hormones. Hypertension 7: 469–482PubMedGoogle Scholar
  4. 4.
    Lang RE, Tholken H, Ganten D, Luft FC, Ruskoaho H, Unger T (1985) Atrial natriuretic factor - a circulating hormone stimulated by volume loading. Nature 314: 264–266PubMedCrossRefGoogle Scholar
  5. 5.
    Imbs JL, Schmidt M, Ehrhardt JD, Schwartz J (1984) The sympathetic nervous system and renal sodium excretion: is dopamine involved? J Cardiovasc Pharmacol 6: S171–S175PubMedCrossRefGoogle Scholar
  6. 6.
    Zidek W, Losse H, Dorst KG, Zumkley H, Vetter H (1982) Intracellular sodium and calcium in essential hypertension. Klin Wschr 60: 859–862PubMedCrossRefGoogle Scholar
  7. 7.
    Whitescarver SA, Ott CE, Jackson BA, Guthrie GP Jr, Kotchen DA (1984) Salt sensitive hyper-tension: contribution of chloride. Science 223: 1430–1432PubMedCrossRefGoogle Scholar
  8. 8.
    McCarron DA, Morris CD, Henry HJ, Stanton JL (1984) Blood pressure and nutrient intake in the United States. Science 224: 1392–1398PubMedCrossRefGoogle Scholar
  9. 9.
    Dworkin LD, Hostetter TH, Rennke HG, Brenner BM (1984) Hemodynamic basis for glomerular injury in rats with desoxycorticosterone–salt hypertension. J Clin Invest 73: 1448–1461PubMedCrossRefGoogle Scholar
  10. 10.
    Redgrave J, Rabinowe S, Hollenberg NK, Williams GH (1985) Correction of abnormal renal blood flow response to angiotensin II by converting enzyme inhibition in essential hypertensives. J Clin Invest 75: 1285–1290PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heildelberg 1986

Authors and Affiliations

  • K. G. Hofbauer
    • 1
  • G. Bönner
    • 2
  1. 1.Biological Research DepartmentCIBA-GEIGY AGBaselSwitzerland
  2. 2.Department of Internal Medicine IIMerheim Hospital and Policlinic of the University of CologneCologne 91Germany

Personalised recommendations