The Kindling Model of Epilepsy of the Hippocampus in the Rat: Electrophysiology and Behavior
Repeated tetanization at regular intervals, i. e., kindling of a brain structure, leads ultimately to the development of an epileptogenic focus. This is the so-called kindling model of epilepsy, described first by Goddard (1967). Several aspects of the phenomenology of the kindling model have been investigated, as reviewed by Racine (1978) and McNamara et al. (1980). In this study, we have tried to reply to two different questions regarding the development of an epileptogenic focus due to kindling: (a) which electrophysiological changes are responsible for this process and (b) can the kindling procedure offer a model not only for motor seizures but also for interictal behavioral deficits?
KeywordsWorking Memory Reference Memory Retrograde Amnesia Stratum Radiatum Schaffer Collateral
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- Creager R, Dunwiddie T, Lynch G (1980) Paired-pulse and frequency facilitation in the CA1 region of the in vitro rat hippocampus. J Physiol 229: 409–424Google Scholar
- Lopes da Silva FH, Wadman WJ, Arnolds DEAT, Veeken C, Holsheimer J (1984) Hippocampus: behaviour and modulation of local circuits. In: Reinoso-Suarez F, Ajmone-Marsan C (eds) Cortical integration. Raven, New York, pp 147–170Google Scholar
- O’Keefe J, Nadel L (1978) The hippocampus as a cognitive map. Clarendon, OxfordGoogle Scholar
- Storm-Mathisen J, OttersenOP (1984) Neurotransmitters in the hippocampal formation. In: Reinoso-Suarez F, Ajmone- MarsanC (eds) Cortical integration. Raven, New York, pp 105–130Google Scholar