The Kindling Model of Epilepsy of the Hippocampus in the Rat: Electrophysiology and Behavior

  • F. H. Lopes Da Silva
Conference paper


Repeated tetanization at regular intervals, i. e., kindling of a brain structure, leads ultimately to the development of an epileptogenic focus. This is the so-called kindling model of epilepsy, described first by Goddard (1967). Several aspects of the phenomenology of the kindling model have been investigated, as reviewed by Racine (1978) and McNamara et al. (1980). In this study, we have tried to reply to two different questions regarding the development of an epileptogenic focus due to kindling: (a) which electrophysiological changes are responsible for this process and (b) can the kindling procedure offer a model not only for motor seizures but also for interictal behavioral deficits?


Working Memory Reference Memory Retrograde Amnesia Stratum Radiatum Schaffer Collateral 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • F. H. Lopes Da Silva
    • 1
  1. 1.Department of ZoologyUniversity of AmsterdamAmsterdamThe Netherlands

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