Hodology of Limbic and Related Structures: Cortical and Commissural Connections

  • D. N. Pandya
  • E. H. Yeterian


A number of theories have been suggested to account for the genesis of seizures. For example, seizures could arise as a result of disinhibition of reciprocal cortical pathways. Alternatively, it could be that an overactivation of afferent and efferent cortical pathways is the basis of seizure phenomena. Another notion proposes that seizures arise from antidromic stimulation of cortical axons of passage which course through deeper structures. Finally, seizures could result from an abnormal reorganization of higher pathways during development. Thus, it seems that seizures could arise from any point in the cortex as a result of any one of these possible mechanisms. Nevertheless, the most common site of seizure genesis is in the deep structures of the temporal and frontal lobes. In this chapter, we wish to present an anatomical viewpoint on how these cortical structures, especially in the temporal lobe, may underlie various seizure phenomena.


Corpus Callosum Temporal Lobe Epilepsy Entorhinal Cortex Superior Temporal Gyrus Anterior Commissure 
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© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • D. N. Pandya
    • 1
    • 2
    • 3
  • E. H. Yeterian
    • 1
    • 4
  1. 1.Edith Nourse Rogers Memorial Veterans HospitalBedfordUSA
  2. 2.Departments of Anatomy and NeurologyBoston University School of MedicineBostonUSA
  3. 3.Harvard Neurological UnitBeth Israel HospitalBostonUSA
  4. 4.Department of PsychologyColby CollegeWatervilleUSA

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