Skip to main content
SpringerLink
Log in

Squamous Cell Carcinomas

  • Chapter
Book cover Tumours of the Larynx

Abstract

Most malignant neoplasms of the larynx and the adjacent regions (hypopharynx and oropharynx with lingual epiglottic surface, valleculae, lower part of the retrolingual region) are squamous cell carcinomas (Table 5.1). In a survey of 1207 patients with malignant tumours of the larynx treated in the Frankfurt University Ear, Nose and Throat Clinic between 1962 and 1986, there were 998 squamous cell carcinomas; including the variants of the squamous cell carcinoma, i.e. the so-called carcinosarcoma, spindle cell carcinoma and verrucous carcinoma, results a good 97%, whereas all other types of malignant neoplasm were seen very rarely.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • AJC — American Joint Committee for Cancer Staging and End Results Reporting (1972): Clinical Staging System for Cancer of the Larynx. Chicago

    Google Scholar 

  • AJC — American Joint Committee for Cancer Staging and End Results Reporting (1977): Manual of Staging of Cancer. Lippincott, Philadelphia

    Google Scholar 

  • AJCC — American Joint Committee on Cancer (1983): Manual for staging of cancer. Lippincott, Philadelphia

    Google Scholar 

  • ALBERTI PW, BRYCE DP (1976): Centennial Conference on Laryngeal Cancer. Appleton–Century–Crofts, New York

    Google Scholar 

  • VON ALBERTINI A, ROULET FC (1974): Histologische Geschwulstdiagnostik. 2nd edn. Thieme, Stuttgart

    Google Scholar 

  • Beck C, Mann W (1980): The inner laryngeal lymphatics. A lymphangioscopical and electron miroscopical study. Acta Otolaryngol (Stockh) 89: 265–270

    Article  CAS  Google Scholar 

  • BOCCA E (1968): Supraglottis surgery of the larynx. Ann Otol Rhinol Laryngol 77: 1005–1026

    PubMed  CAS  Google Scholar 

  • BOCCA E (1975): Limitations of supraglottic laryngectomy and conservative neck dissection. Can J Otolaryngol 4: 403–419

    PubMed  CAS  Google Scholar 

  • BOCCA E (1975): Supraglottic cancer. Laryngoscope 85: 1318–1326

    Article  PubMed  CAS  Google Scholar 

  • BOHNDORF W, HöCKER G (1976): Würzburger Ergebnisse beim Larynxkarzinom. Strahlentherapie 151: 132–143

    PubMed  CAS  Google Scholar 

  • BRIDGER GP (1974): Mucous gland involvement in cancer at the anterior commissure. Can J Otolaryngol 3: 507–511

    PubMed  CAS  Google Scholar 

  • BRIDGER GP, NASSAR VH (1972): Cancer spread in the larynx. Arch Otolaryngol 95: 497–505

    PubMed  CAS  Google Scholar 

  • BRODERS AC (1920): Squamous-cell epithelioma of the lip. JAMA 74: 656–664

    Google Scholar 

  • BRODERS AC (1921): Squamous-cell epithelioma of skin: A study of 256 cases. Ann Surg 73: 141–160

    Article  PubMed  CAS  Google Scholar 

  • BRODERS AC (1922): Epithelioma of the genitourinary organs. Ann Surg 75: 574–604

    Article  PubMed  CAS  Google Scholar 

  • BRODERS AC (1925): Cancer’s selfcontrol. Med J Rec 121: 133–135

    Google Scholar 

  • BRODERS AC (1932a): Practical points on the microscopic grading of carcinoma. N Y State J Med 32: 667–671

    Google Scholar 

  • BRODERS AC (1932b): Carcinomas in situ contrasts with benign penetrating epithelium. JAMA 99: 1670–1674

    Google Scholar 

  • BRODERS AC (1940): Grading of cancer. In: PACK GT, LIVINGSTON EM (eds), Treatment of cancer and allied diseases; 1st edn. Hoeber, New York

    Google Scholar 

  • BROYLES EN (1943): The anterior commissure tendon. Ann Otol Rhinol Laryngol 52: 342–345

    Google Scholar 

  • BRYCE DP (1972): Convential pharyngolaryngectomy in the surgical management of hypopharyngeal cancer. Can J Otolaryngol 1: 231–244

    Google Scholar 

  • BURKHARDT A (1980): Der Mundhöhlenkrebs und seine Vorstadien. Ultrastrukturelle und immunpathologische Aspekte. Fischer, Stuttgart-New York

    Google Scholar 

  • CANN CI, FRIED P (1984): Determinants and prognosis of laryngeal cancer. Otolaryngol Clin North Am 17: 139–150

    PubMed  CAS  Google Scholar 

  • CHUNG CK, STRYKER JA, ABT AB, CUNNINGHAM DE, STRAUSS M, CONNOR GH (1980): Histologic grading in the clinical evaluation of laryngeal carcinoma. Arch Otolaryngol 106: 623–624

    PubMed  CAS  Google Scholar 

  • COATES HL, DESANTO LW, DEVINE KD, ELVEBACK LR (1976): Carcinoma of the supraglottic larynx. A review of 221 cases. Arch Otolaryngol 102: 686–689

    PubMed  CAS  Google Scholar 

  • CINBERG JZ, CHANG TH, BASES R, MOLNAR J (1980): The percentage of cells in DNA synthesis in epidermoid carcinomas of the head and neck: a preliminary report. Laryngoscope 90: 920–923

    PubMed  CAS  Google Scholar 

  • DENOIX PF (1944): Bull Inst Nat Hyg (Paris) 1: 1–69; 5: 52–82

    Google Scholar 

  • EDMUNDSON WF (1948): Microscopic grading of cancer and its practical implication. Arch Derm Syphil 57: 141–160

    CAS  Google Scholar 

  • FLEISCHER I (1977): Morphologische Untersuchungen an subglottischen Kehlkopfkarzinomen. Inauguraldissertation, Marburg

    Google Scholar 

  • GANZER U, MEYER-BREITING E, EBBERS J, VOSTEEN K-H (1982): Der Einfluβ von Tumorgröβe, Lymphknotenbefall und Behandlungsart auf die Prognose des Hypopharynxkarzinoms. Laryngol Rhinol Otol 61: 622–628

    Article  CAS  Google Scholar 

  • GANZER U, SENDROWSKI P, VOSTEEN K-H, MEYER-BREITING P (1981): Die kombinierte radiochirurgische Behandlung des fortgeschrittenen Kehlkopfkarzinoms (T3-4, NO-3). Ein retrospektiver Vergleich zwischen Sandwich-Technik und postoperativer Bestrahlung. Laryngol Rhinol Otol 60: 63–70

    Article  CAS  Google Scholar 

  • GLANZ HK (1981): Die prognostische Bedeutung des histologischen gradings von Stimmlippenkarzinomen. Arch Otorhinolaryngol 231: 745–746

    Article  Google Scholar 

  • GLANZ HK (1984): Carcinoma of the larynx; growth, p-classification and grading of squamous cell carcinoma of the vocal cords. Adv Otorhinolaryngol 32: 1–123

    PubMed  CAS  Google Scholar 

  • GLANZ HK, EICHHORN Th (1985): Die Bedeutung des histologischen “gradings” von Stimmlippenkarzinomen. HNO 33: 103–111

    PubMed  CAS  Google Scholar 

  • GRAEM N, HELWEG-LARSEN K, KEIDING N (1980): Precision of histological grading of malignancy. Acta Pathol Microbiol Immunol Scand (A) 88: 307–317

    CAS  Google Scholar 

  • GUDZIOL H, BELEITES E (1983): über die Häufigkeit regionärer Metastasen beim supraglottischen Karzinom. Laryngol Rhinol Otol 62: 35–37

    Article  CAS  Google Scholar 

  • GüNNEL F, Baerthold W (1967): Zur Frage der Teilresektion bei Kehlkopfkrebsen. Arch Otorhinolaryngol 189: 195–209

    Google Scholar 

  • HAMPERL H (1967): Early invasive growth as seen in uterine cancer and the role of the basal membrane. In: DENOIX P (edr), Mechanisms of invasion in cancer. UICC Monography, vol 6. Springer, Berlin-Heidelberg-New York

    Google Scholar 

  • HANSEMANN D (1890): über asymmetrische Zellteilung in Epithelkrebsen und deren biologische Bedeutung. Virchows Arch(A) 119: 299–326

    Article  Google Scholar 

  • HARRISON DFN (1972): Thyroid gland in the management of laryngopharyngeal cancer. Arch Otolaryngol 7: 301–302

    Google Scholar 

  • HARRISON DFN (1979): Intrinsic weakness of the T N M system for classification of laryngeal cancer. ORL 41: 241–251

    Article  PubMed  CAS  Google Scholar 

  • HAST MH (1974): Applied embryology of the larynx. Can J Otolaryngol 3: 412–415

    PubMed  CAS  Google Scholar 

  • HELWEG-LARSEN K, GRAEM N, MEISTRUP-LARSEN K-I, MEISTRUP-LARSENK U (1978): Clinical relevance of histological grading of cancer of the larynx. Acta Pathol Microbiol Immunol Scand (A) 86: 499–504

    Google Scholar 

  • Hermanek P, Sobin LH (1987): TNM classification of malignant tumours. 4th fully revised edition. Springer, Berlin — Heidelberg — New York — Paris — Tokyo

    Google Scholar 

  • HOFFMANN I (1968): Morphologische Untersuchungen an 60 Kehlkopfeingangskarzinomen. Inauguraldissertation, Köln

    Google Scholar 

  • HOLM LE, JAKOBSSON P, KILLANDER D, SILFVERSWäRD C, WERSäLL J (1980): DNA and its synthesis in indivdual tumor cells from human upper respiratory tract squamous cell carcinomas. Laryngoscope 90: 1209–1212

    Article  PubMed  CAS  Google Scholar 

  • HOMMERICH KW, SAUER H, WEEDE W (1971): Zur Wachstumstendenz von Larynxtumoren. Arch Otorhinolaryngol 199: 748–751

    CAS  Google Scholar 

  • JAKOBSSON PA, ENEROTH CM, KILLANDER D et al (1973): Histological classification and grading of malignancy in cancer of the larynx. Acta Radiol Oncol 12: 1–8

    Article  CAS  Google Scholar 

  • JOERGENSEN K, SELL A (1971): Carcinoma of the larynx II. Treatment by 60-Co supervoltage irradiation. Acta Radiol (Oncol) 10: 161–173

    Article  Google Scholar 

  • KASHIMA HK (1976): The characteristics of laryngeal cancer correlating with cervical lymph node metastasis. In: ALBERTI PW, BRYCE DP (eds), Centennial Conference on Laryngeal Cancer, pp 855–864. Appleton-Century-Crofts, New York

    Google Scholar 

  • KIRCHNER JA (1969): One hundred laryngeal cancers studied by serial section. Ann Otol Rhinol Laryngol 78: 689–709

    PubMed  CAS  Google Scholar 

  • KIRCHNER JA (1970): Cancer at the anterior commissure of the larynx. Arch Otolaryngol 91: 524–525

    PubMed  CAS  Google Scholar 

  • KIRCHNER JA (1975a): Pyriforms sinus cancer: A clinical and laboratory study. Ann Otol Rhinol Laryngol 84: 793–804

    PubMed  CAS  Google Scholar 

  • KIRCHNER JA (1975b): Staging as seen in serial sections. Laryngoscope 85: 1816–1821

    Article  PubMed  CAS  Google Scholar 

  • KIRCHNER JA (1977): Two hundred laryngeal cancers. Patterns of growth and spread as seen in serial section. Laryngoscope 87: 474–482

    Article  PubMed  CAS  Google Scholar 

  • KIRCHNER JA, FISCHER JJ (1975): Anterior commissure cancer — A clinical and laboratory study of 39 cases. Can J Otolaryngol 4: 637–643

    PubMed  CAS  Google Scholar 

  • KIRCHNER JA, OWEN JR (1977): Five hundred cancers of the larynx and pyriform sinus. Results of treatment by radiation and surgery. Laryngoscope 87: 1288–1303

    Article  PubMed  CAS  Google Scholar 

  • KIRCHNER JA, SOM ML (1971): Clinical and histological observations on supraglottic cancer. Ann Otol Rhinol Laryngol 80: 638–645

    PubMed  CAS  Google Scholar 

  • KIRCHNER JA, CORNOG JL, HOMES RE (1974): Transglottic cancer. Arch Otolaryngol 99: 247–251

    PubMed  CAS  Google Scholar 

  • KLEINSASSER O (1967): Wachstumsformen der Kehlkopfeingangscarcinome und Indikation zur Teilresektion. Wiss Z Karl-Marx-Univ (Lpz) 16: 723–725

    Google Scholar 

  • KUS J, MIODONSKI A, OLSZEWSKI E, TYRANKIESWICZ R (1981): Morphology of arteries, veins, and capillaries in cancer of the larynx. J Cancer Res Clin Oncol 100: 271–283

    Article  PubMed  CAS  Google Scholar 

  • LAM KH (1983): Three preepiglottic and paraglottic spaces in relation to spread of carcinoma of the larynx. Am J Otolaryngol 4: 81–91

    Article  PubMed  CAS  Google Scholar 

  • LAM KH (1983): Extralaryngeal spread of cancer of the larynx: a study with whole-organ sections. Head Neck Surg 5: 410–424

    Article  PubMed  CAS  Google Scholar 

  • Löbe L-P, Quade R (1982): Histopathologisches Grading von Karzinomen des HNO-Gebietes. Laryngol Rhinol Otol 61: 171–173

    Article  Google Scholar 

  • LOTT S, EL-MAHDI AM, HAZRA T (1972): Supervoltage radiotherapy for carcinoma of the larynx. The Johns Hopkins Hospital results 1961–1967. Johns Hopkins Med J 130: 244–253

    PubMed  CAS  Google Scholar 

  • LUND C, SOGAARD H, JORGENSEN K, HJELM-HANSEN M (1975): Epidermoid carcinoma of the larynx. Radiol Ther Physics Biol 15: 293

    Google Scholar 

  • MARTENSSON B, FLUUR E, JAKOBSSON F (1967): Aspects on treatment of cancer of the larynx. Ann Otol Rhinol Laryngol 76: 313–329

    PubMed  CAS  Google Scholar 

  • MCCOMB WS, FLETCHER GH, GALAGER HS, HEALY JE, LEHMANN OH (1967): Larynx. In: MCCOMB WS, FLETCHER GH (eds), Cancer of the head and neck. Baltimore

    Google Scholar 

  • MCGAVRAN MH, BAUER WC, OGURA JH (1961): The incidence of cervical lymph node metastases from epidermoid carcinoma of the larynx and their relationship to certain characteristics of the primary tumor. Cancer 14: 55–66

    Article  PubMed  CAS  Google Scholar 

  • MENDONCA DR, BRYCE DP (1973): Transglottic cancer of the larynx. Can J Otolaryngol 2: 271–276

    Google Scholar 

  • MEYER-BREITING E (1981a): Zur Histopathologic bestrahlter und nicht bestrahlter Kehlkopfkarzinome. Habilitationsschrift, Frankfurt

    Google Scholar 

  • MEYER-BREITING E (1981b): Histologisches Verhalten und Prognose fortgeschrittener Plattenepithelkarzinome. Arch torhinolaryngol 231: 746–750

    Article  Google Scholar 

  • MEYER-BREITING E,VON ILBERG Ch (1979): Spread and mode of metastasis of supraglottic laryngeal carcinoma ORL 41: 288–300

    Article  PubMed  CAS  Google Scholar 

  • MEYER-BREITING E, POPESCU G (1986): Zur Definition der Glottischen Region. Arch Otorhinolaryngol Suppl 1986 /II: 150–152

    Google Scholar 

  • MEYER-BREITING E, SCHNEIDER B (1981): Plattenepithelkarzinome an der vorderen Kommissur und Penetration des Kehlkopfgerüstes. Laryngol Rhinol Otol 60: 89–95

    Article  CAS  Google Scholar 

  • MEYER-BREITING E, SCHORM-EWERS P (1987): Zur T-Klassifikation des Larynxkarzinoms — eine klinisch pathohistologische Studie. In: MAJER EH, ZRUNEK M (eds), Die Oto-Rhino-Laryngologie in Kooperation mit Nachbardisziplinen; pp 222–225. Facultas, Wien

    Google Scholar 

  • MITTAL B, MARKS JE, OGURA JH (1984): Transglottic carcinoma. Cancer 53: 151–161

    Article  PubMed  CAS  Google Scholar 

  • MüLLER E (1966): Über den Befall des Gerüstes beim inneren Kehlkopfkarzinom. Laryngol Rhinol Otol 45: 512–523

    Google Scholar 

  • NORRIS CM, TUCKER GF, BURNS KF, PITSER WF (1970): A correlation of clinical staging, pathological findings and five year end results in surgically treated cancer of the larynx. Ann Otol Rhinol Laryngol 79: 1033–1048

    PubMed  CAS  Google Scholar 

  • OGURA JH (1955): Surgical pathology of cancer of the larynx. Laryngoscope 65: 867–926

    Article  Google Scholar 

  • OGURA JH (1958): Supraglottic subtotal laryngectomy and radical neck dissection for carcinoma of the epiglottis. Laryngoscope 68: 983–1003

    Article  PubMed  CAS  Google Scholar 

  • OLOFSSON H,VAN NOSTRAND AWP (1973): Growth and spread of laryngeal carcinoma with reflections on the effect of preoperative irradiation. Acta Otolaryngol (Stockh) Suppl 308: 1–84

    CAS  Google Scholar 

  • OLOFSSON J, WILLIAMS GT, RIDER WD, BRYCE DP (1972): Anterior commissure carcinoma. Arch Otolaryngol 95: 230–239

    PubMed  CAS  Google Scholar 

  • PARK WW (1980): The histology of borderline cancer with notes on prognosis. Springer, Berlin-Heidelberg-New York

    Book  Google Scholar 

  • PIETRANTONI L, AGAZZI C, FIOR (1961): Le problème ganglionnaire dans le traitement des cancers du larynx et résultats aprés 5 ans. Adv Otorhinolaryngol 9: 275–323

    CAS  Google Scholar 

  • PRESSMAN JJ, SIMON MB, MONELL C (1960): Anatomical studies related to the dissemination of cancer of the larynx. Trans Am Acad Ophthalmol Otolaryngol 64: 628–638

    PubMed  CAS  Google Scholar 

  • ROSEMANN G (1963): Über das Vorkommen multizentrischer Carcinomata in situ und Karzinome der Epiglottis. Laryngol Rhinol Otol 42: 641–654

    CAS  Google Scholar 

  • ROUVIERE H (1932): Anatomie des lymphatiques de l’homme. Masson und Cie., Paris

    Google Scholar 

  • ROUVIERE H (1938): Anatomy of the human lymphatic system. Edwards Brothers, Inc., Ann Arbor

    Google Scholar 

  • SCHWAB W,ZUM WINKEL J (1975): Möglichkeiten der Strahlentherapie in der Hals-Nasen-Ohrenheilkunde. Thieme, Stuttgart

    Google Scholar 

  • SMITH RR, CAULK RM, RUSSEL WO, JACKSON CL (1961): End results in 1600 laryngeal cancers using the American Joint Committee’s proposed method of stage classification and end results reporting. Surg Gynecol Obstet 113: 435–444

    Google Scholar 

  • SMITH RR, CAULK R, FRAZELL E, HOLINGER PH, MCCOMB WS, RUSSELL WO et al (1973): Revision of the clinical staging system for cancer of the larynx. Cancer 31: 72–80

    Article  PubMed  CAS  Google Scholar 

  • SZLESAK L (1966): Histological serial block examination of 57 cases of laryngeal cancer. Oncologia 20: 178–194

    Article  Google Scholar 

  • TASKINEN PJ (1969): Radiotherapy and TNM-classification of cancer of the larynx. Acta Radiol (Suppl)(Stockh) 287

    Google Scholar 

  • TUCKER GF (1963): Some clinical inferences from the study of serial laryngeal sections. Laryngoscope 73: 728–748

    Article  PubMed  Google Scholar 

  • TUCKER GF (1971): Human larynx coronal section atlas. Armed Forces Institute of Pathology, Washington DC

    Google Scholar 

  • TUCKER GF (1973): The anterior commissure revisited. Ann Otol Rhinol Laryngol 625–636

    Google Scholar 

  • TUCKER GF (1974): The anatomy of laryngeal cancer. Can J Otolaryngol 3: 417–427

    PubMed  Google Scholar 

  • UICC (International Union Against Cancer) (1958): Clinical stage classification and presentation of results. Malignant tumours of the breast and larynx. Paris

    Google Scholar 

  • UICC Union Internationale Contre le Cancer (1968): TNM classification of malignant tumours. (Larynx and Hypopharynx). Classified 1962. Genf

    Google Scholar 

  • UICC Union Internationale Contre le Cancer (1972): TNMclassification of malignant tumours of breast, larynx, stomach, cervix uteri, corpus uteri. Genf

    Google Scholar 

  • UICC Union Internationale Contre le Cancer (1978): Report of Committee on TNM Classification. Geneva

    Google Scholar 

  • UICC Union Internationale Contre le Cancer (1979): TNM-Klassifikation der malignen Tumoren. 3. Aufl. Springer, Berlin-Heidelberg-New York

    Google Scholar 

  • WAHI PN, COHEN B, LUTHRA UK, TORLONI H (1971): Histological typing of oral and oropharyngeal tumours. WHO, Geneva

    Google Scholar 

  • WEEDE W (1974): Histolgische Untersuchungen über die Wachstumstendenzen supraglottischer Kehlkopftumoren. Inauguraldissertation, Berlin

    Google Scholar 

  • WELSH LW (1964): The normal human laryngeal lymphatics. Ann Otol Rhinol Laryngol 73: 569–582

    PubMed  CAS  Google Scholar 

  • WELSH LW, WELSH JJ, BEHLKE FM (1961): Surgical alterations of the laryngeal lymphatics. Ann Otol Rhinol Laryngol 70: 52–63

    PubMed  CAS  Google Scholar 

  • WHO — World Health Organization (1976): ICD-O (International Classification of Diseases for Oncology). 1st edn. WHO, Geneva

    Google Scholar 

  • WHO — World Health Organization (1979): ICD-O (International Classification of Diseases for Oncology): Tumor-Lokalisationsschlüssel. Springer, Berlin — Heidelberg — New York

    Google Scholar 

  • YEAGER VL, ARCHER CR (1982): Anatomical routes for cancer invasion of laryngeal cartilages. Laryngoscope 92: 449–452

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Zentrum der HNO-Heilkunde, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, D-6000, Frankfurt am Main 70, Germany

    Priv.-Doz. Dr. Erhard Meyer-Breiting

  2. Pathologisches Institut, der Universität Bern, Freiburg Str. 30, CH-3010, Bern, Germany

    Professor Dr. Arne Burkhardt

Authors
  1. Priv.-Doz. Dr. Erhard Meyer-Breiting
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Professor Dr. Arne Burkhardt
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Meyer-Breiting, E., Burkhardt, A. (1988). Squamous Cell Carcinomas. In: Tumours of the Larynx. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71100-8_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71100-8_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71102-2

  • Online ISBN: 978-3-642-71100-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation