Papillomaviruses and Human Disease

pp 40-103

Papillomavirus Infections in Animals

  • J. P. Sundberg

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Papillomaviruses have been associated with a number of hyperplastic and neoplastic lesions in a wide variety of vertebrate species (Tables 1–3). In humans, induced lesions are usually papillomas, some of which, notably those of the lower genital tract and skin, may progress to squamous cell carcinomas. It is now known that many genetically different papillomaviruses infect human beings, that specific types have predilections for particular anatomical sites, and certain types are known to be associated with lesions that progress to carcinoma. It is not surprising to find that similar, if not identical, situations exist in other animal species.