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Mononuclear Phagocyte Function in the Perinatal Period

  • Conference paper
Immunology of the Neonate

Abstract

The monocyte-macrophage lineage represents a primitive first line of defense, maintained and refined in evolution. In higher organisms, while retaining their basic role of primary line of resistance, phagocytic cells have become integrated into the subsequently evolved mechanisms of specific immunity. Cooperation between lymphoid cells and macrophages occurs at different levels in the genesis of immune responses, and, in inflammatory sites, they play important roles in the expression of cell-mediated immune reactions. The role played by mononuclear phagocytes in resistance against infectious agents has long been recognized. Age-dependent resistance to infectious agents is a well-known phenomenon and host responses to a range of microorganisms, including bacteria, mycobacteria, yeasts, parasites, and viruses are relatively poor in the perinatal period in humans (Weston et al. 1977; Bellanti and Hurtado 1976). Considerable evidence has accumulated that selected functions of mononuclear phagocytes are defective in newborns and that this defect of the mononuclear phagocyte system plays a crucial role in increased susceptibility to some infectious agents (Pitt et al. 1977). In this review we will concisely discuss selected aspects of mononuclear phagocyte function in the perinatal period, emphasizing the selectivity of alterations. Some recent results on the immunobiology of placental and breast milk macrophages will also be mentioned, since, in addition to having attracted our attention, they have an obvious bearing on resistance in the perinatal period.

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Author information

Authors and Affiliations

  1. Istituto di Ricerche Farmacologiche “Mario Negri”, Milano, Italy

    A. Biondi, G. Poli & A. Mantovani

  2. Cattedra di Anatomia e Istologia Patologica V, Università di Milano, Italy

    C. Parravicini

  3. Clinica Ostetrica e Ginecologica, Università di Milano, Osp. L. Sacco, Italy

    A. Molinari

Authors
  1. A. Biondi
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  2. G. Poli
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  3. C. Parravicini
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  4. A. Molinari
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  5. A. Mantovani
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Editor information

Editors and Affiliations

  1. Clinica Pediatrics, Universitá di Pavia, I-27100, Pavia, Italy

    G. Roberto Burgio

  2. Institute of Clinical Microbiology, University of Götebôrg, Guldhedsgatan 10, S-413 46, Göteborg, Sweden

    Lars Åke Hanson

  3. Clinica Pediatrica Ospedale dei Bambini, University of Brescia, Via del Medolo 2, I-25100, Brescia, Italy

    Alberto G. Ugazio

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© 1987 Springer-Verlag Berlin Heidelberg

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Biondi, A., Poli, G., Parravicini, C., Molinari, A., Mantovani, A. (1987). Mononuclear Phagocyte Function in the Perinatal Period. In: Burgio, G.R., Hanson, L.Å., Ugazio, A.G. (eds) Immunology of the Neonate. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71094-0_6

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  • DOI: https://doi.org/10.1007/978-3-642-71094-0_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71096-4

  • Online ISBN: 978-3-642-71094-0

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