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Development of Lymphocyte Responses to Herpes Simplex Virus Following Neonatal Infection

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Immunology of the Neonate

Abstract

Children with congenital cytomegalovirus infection continue to shed the virus in their urine for several years, and survivors of neonatal herpes simplex virus (HSV) infection have recurrent crops of skin vesicles caused by HSV in infancy. Both observations suggest that immune responses to these viruses are limited following congenital or neonatal infection. Affected children have few T cells in their blood, which proliferate in response to the infecting virus (Hayward et al. 1984a). However, the presence of first IgM and later IgG antibodies to HSV in their serum indicates that they have developed specific immunity and suggests that they have T cells capable of providing help to B cells (Hayward et al. 1984b).

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Author information

Authors and Affiliations

  1. Departments of Pediatrics, University of Colorado School of Medicine and Stanford University, Denver, CO, 80262, USA

    Anthony Hayward, Paul Leibson & Ann Arvin

Authors
  1. Anthony Hayward
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  2. Paul Leibson
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  3. Ann Arvin
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Editor information

Editors and Affiliations

  1. Clinica Pediatrics, Universitá di Pavia, I-27100, Pavia, Italy

    G. Roberto Burgio

  2. Institute of Clinical Microbiology, University of Götebôrg, Guldhedsgatan 10, S-413 46, Göteborg, Sweden

    Lars Ã…ke Hanson

  3. Clinica Pediatrica Ospedale dei Bambini, University of Brescia, Via del Medolo 2, I-25100, Brescia, Italy

    Alberto G. Ugazio

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© 1987 Springer-Verlag Berlin Heidelberg

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Hayward, A., Leibson, P., Arvin, A. (1987). Development of Lymphocyte Responses to Herpes Simplex Virus Following Neonatal Infection. In: Burgio, G.R., Hanson, L.Ã…., Ugazio, A.G. (eds) Immunology of the Neonate. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71094-0_12

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  • DOI: https://doi.org/10.1007/978-3-642-71094-0_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71096-4

  • Online ISBN: 978-3-642-71094-0

  • eBook Packages: Springer Book Archive

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