Abstract
In previous studies of several techniques of pancreas transplantation in the rat, we observed histologic changes in both duct-ligated and duct-occluded segmental grafts that led not only to an expected atrophy of exocrine tissue, but also to deformation and disintegration of islets (Schang et al. 1985). In contrast, draining of exocrine secretion led to a situation in which morphologically unaltered isografts were not distinguishable from a normal pancreas 300 days after transplantation. The simplest and most reliable technique of exocrine secretion drainage was revealed to be the pancreaticoduodenal graft described by Lee et al. (1972). Therefore, we used this technique for a rejection study of allogeneic pancreas grafts in the rat. The aim of the study was to describe the course of rejection of allografts in untreated and in temporarily immunosuppressed recipients, with special regard to comparing the rejection of duodenal and pancreactic tissue.
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References
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© 1986 Springer-Verlag Berlin Heidelberg
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Schang, T., Timmermann, W., Schubert, G., Thiede, A. (1986). Course of Rejection in Pancreaticoduodenal Allografts in the Rat. In: Deltz, E., Thiede, A., Hamelmann, H. (eds) Small-Bowel Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71087-2_27
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DOI: https://doi.org/10.1007/978-3-642-71087-2_27
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71089-6
Online ISBN: 978-3-642-71087-2
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