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Rejection in Orthotopic Small-Bowel Transplantation and Immunosuppression by Cyclosporine A: Evidence for Development of Tolerance Mechanisms

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Small-Bowel Transplantation

Abstract

The immunologic response in small-intestine transplantation is characterized by an interaction between rejection and graft-versus-host reaction (GvHR) (Deltz 1981). In a fully allogeneic donor-recipient combination, an interaction of both reactions occurs (Deltz 1984). As has been shown in previous investigations, a GvHR may not develop in the case of strong rejection reactions. In this situation, rejection predominates. Therefore, we investigated rejection after orthotopic small-bowel transplantation and tried to elaborate the patterns of T cell infiltration in the graft in order to characterize the course of rejection without immunosuppression and during administration of cyclosporine A (CsA).

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References

  • Deltz E (1984) Die allogene Dünndarmtransplantation. Zuckschwerdt, Munich

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  • Deltz E, Müller-Hermelink HK, Ulrichs K, Thiede A, Müller-Ruchholtz W (1981) Development of graft-versus-host reaction in various target organs after small intestine transplantation. Transplant Proc 13: 1215–1216

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  • Deltz E, Ulrichs K, Schack T, Friedrichs B, Müller-Ruchholtz W, Müller-Hermelink HK, Thiede A (1986) Graft versus host reaction in small intestine transplantation and possibilities for its circumvention. Am J Surg 151: 379–386

    Article  PubMed  CAS  Google Scholar 

  • Kirkman RL, Lear PA, Madara JC, Tilney NC (1984) Small intestine transplantation in the rat: Immunology and Function. Surgery 96: 280–287

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  • Madara JC, Kirkman RC (1985) Structural and functional evolution of jejunal allograft rejection in rats and the ameliorating effects of cyclosporine therapy. J Clin Invest 75: 502–512

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© 1986 Springer-Verlag Berlin Heidelberg

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Preissner, W.C., Liedgens, P., Gundlach, M., Schröder, E., Müller-Hermelink, H.K., Deltz, E. (1986). Rejection in Orthotopic Small-Bowel Transplantation and Immunosuppression by Cyclosporine A: Evidence for Development of Tolerance Mechanisms. In: Deltz, E., Thiede, A., Hamelmann, H. (eds) Small-Bowel Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71087-2_26

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  • DOI: https://doi.org/10.1007/978-3-642-71087-2_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71089-6

  • Online ISBN: 978-3-642-71087-2

  • eBook Packages: Springer Book Archive

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