Epithelial Tumors

  • Mark R. Wick
  • Juan Rosai


Over the past 25 years, the definition, diagnosis, and treatment of thymic epithelial tumors has been refined continually. The group of neoplasms formerly designated generically as “thymomas” has now been divided into several distinct clinicopathologic entities (Bernatz et al. 1961; Lattes 1962; Katz and Lattes 1969; Rosai and Higa 1972; Levine 1973; Sterchi and Cordell 1975; Rosai and Levine 1976; Levine and Rosai 1978; Gray and Gutowski 1979, Snover et al. 1982; Wick et al. 1982; Lewis et al. 1987). The true spectrum of the morphological appearance and behavior of thymomas (i. e., cytologically bland tumors of the thymic epithelium) has thus been better characterized.


Spindle Cell Embryonal Carcinoma Thymic Carcinoma Thymic Epithelial Cell Thymic Cyst 
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  1. Aguirre P, Scully RE, Dayal Y, DeLellis RA (1985) Placentalike alkaline phosphatase in germ cell tumors of the ovary and testis. Lab Invest 52: 2 AGoogle Scholar
  2. Arriagada R, Gerard-Marchant R, Tubiana M, Amiel JL, Hajj L (1981) Radiation therapy in the management of malignant thymic tumors. Acta Radiol [Oncol] 20: 167–172CrossRefGoogle Scholar
  3. Bach JF (1979) Thymic hormones. J Immunopharmacol 1: 277–310PubMedCrossRefGoogle Scholar
  4. Banks PM, Arseneau JC, Gralnick HR, Canellos GP, DeVita VT Jr, Berard CW (1975) American Burkitt’s lymphoma: a clinicopathologic study of 30 cases. II. Pathologic correlations. Am J Med 58: 322–329Google Scholar
  5. Battifora H, Sun TT, Bahu RM, Rao S (1980) The use of an- tikeratin antiserum as a diagnostic tool: thymoma versus lymphoma. Hum Pathol 11: 635–641PubMedCrossRefGoogle Scholar
  6. Battifora H, Sheibani K, Tubbs RR, Kopinski MI, Sun TT (1984) Antikeratin antibodies in tumor diagnosis: distinction between seminoma and embryonal carcinoma. Cancer 54: 843–848PubMedCrossRefGoogle Scholar
  7. Baud M, Stamenkovic I, Kapanci Y (1981) Malignant thymomas: clinicopathologic study of 13 cases. In: Fenoglio CM, Wolff M (eds) Progress in surgical pathology, vol 3. Masson, New York, pp 129–146Google Scholar
  8. Bedford GV (1930) A case of carcinoma of the thymus with extensive metastases in a new-born child. Can Med Assoc J 23: 197–202PubMedGoogle Scholar
  9. Bergh NP, Gatzinsky P, Larsson S, Lundin P, Ridell B (1978) Tumors of the thymus and thymic region. I. Clinicopatho- logical studies on thymomas. Ann Thorac Surg 25: 91–98PubMedCrossRefGoogle Scholar
  10. Bernatz PE, Harrison EG Jr, Clagett OT (1961) Thymoma: a clinicopathologic study. J Thorac Cardiovasc Surg 42: 424–444PubMedGoogle Scholar
  11. Bernatz PE, Khonsari S, Harrison EG Jr, Taylor WF (1973) Thymoma: factors influencing prognosis. Surg Clin North Am 53: 885–892PubMedGoogle Scholar
  12. Boston B (1976) Chemotherapy of invasive thymoma. Cancer 38: 49–52PubMedCrossRefGoogle Scholar
  13. Chahinian AP, Bhardwaj S, Meyer RJ, Jaffrey IS, Kirschner PA, Holland JF (1981) Treatment of invasive or metastatic thymoma: report of eleven cases. Cancer 47: 1752–1761PubMedCrossRefGoogle Scholar
  14. Chan WC, Zaatari GS, Tabei S, Bibb M, Brynes RK (1984) Thymoma: an immunohistochemical study. Am J Clin Pathol 82: 160–166PubMedGoogle Scholar
  15. Cooper GN Jr, Narodick BG (1972) Posterior mediastinal thymoma: case report. J Thorac Cardiovasc Surg 63: 561–563PubMedGoogle Scholar
  16. Cox JD (1975) Primary malignant germinal tumors of the mediastinum: a study of 24 cases. Cancer 36: 1162–1168PubMedCrossRefGoogle Scholar
  17. Easton JM, Levine PH, Hyams VJ (1980) Nasopharyngeal carcinoma in the United States: a pathologic study of 177 US and 30 foreign cases. Arch Otorhinolaryngol 106: 88–91Google Scholar
  18. Evans WK, Thompson DM, Simpson WJ, Feld R, Phillips MJ (1980) Combination chemotherapy in invasive thymoma: role of COPP. Cancer 46: 1523–1527PubMedCrossRefGoogle Scholar
  19. Ewing J (1916) The thymus and its tumors: report of three cases of thymoma. Surg Gynecol Obstet 22: 461–472Google Scholar
  20. Fechner RE (1969) Recurrence of noninvasive thymomas: report of four cases and review of the literature. Cancer 23: 1423–1427PubMedCrossRefGoogle Scholar
  21. Fox RM, Woods RL, Tattersall MHN, McGovern VJ (1979) Undifferentiated carcinoma in young men: the atypical teratoma syndrome. Lancet 1: 1316–1318PubMedCrossRefGoogle Scholar
  22. Gafni J, Michaeli D, Heller H (1960) Idiopathic acquired agammaglobulinemia associated with thymoma: report of two cases and review of the literature. N Engl J Med 263: 536 - 541PubMedCrossRefGoogle Scholar
  23. Gravanis MB (1968) Metastasizing thymoma: report of a case and review of the literature. Am J Clin Pathol 49: 690 - 696PubMedGoogle Scholar
  24. Gray GF, Gutowski WT III (1979) Thymoma: a clinicopathologic study of 54 cases. Am J Surg Pathol 3: 235 - 249PubMedCrossRefGoogle Scholar
  25. Griffin JD, Aisenberg AC, Long JC (1978) Lymphocytic thymoma associated with T-cell lymphocytosis. Am J Med 64: 1075 - 1079PubMedCrossRefGoogle Scholar
  26. Haaga JR (1979) New technique for CT-guided biopsies. AJR 133: 633 - 641PubMedGoogle Scholar
  27. Hirst E, Robertson TI (1967) The syndrome of thymoma and erythroblastopenic anemia: a review of 56 cases including 3 case reports. Medicine (Baltimore) 46: 225 - 264CrossRefGoogle Scholar
  28. Jacobson VC (1923) Primary carcinoma of the thymus. Arch Intern Med 31: 847 - 856Google Scholar
  29. Katz A, Lattes R (1969) Granulomatous thymoma or Hodg- kin’s disease of thymus? A clinical and histologic study and a re-evaluation. Cancer 23: 1 - 15PubMedCrossRefGoogle Scholar
  30. Keller AR, Hochholzer L, Castelman B (1972) Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer 29: 670 - 683PubMedCrossRefGoogle Scholar
  31. Klein G (1979) The relationship of the virus to nasopharyngeal carcinoma. In: Epstein MA, Achong BG (eds) The Epstein-Barr virus. Springer, Berlin Heidelberg New York, pp 340–350Google Scholar
  32. Knowles DM II (1985) Lymphoid cell markers. Their distribution and usefulness in the immunopathologic analysis of lymphoid neoplasms. Am J surg Pathol 9 (Suppl): 85–108Google Scholar
  33. Kodama T, Watanabe S, Sato Y, Shimosato Y, Miyazawa N (1986) An immunohistochemical study of thymic epithelial tumors. I. Epithelial component. Am J Surg Pathol 10: 26–33PubMedCrossRefGoogle Scholar
  34. Kurman RJ, Seardino PT, Mclntire KR, Waldmann TA, Ja- vadpour N (1977) Cellular localization of alpha-fetoprotein and human chorionic gonadotropin in germ cell tumors of the testis using an indirect immunoperoxidase technique: a new approach to classification utilizing tumor markers. Cancer 40: 2136–2151PubMedCrossRefGoogle Scholar
  35. Kurtin PJ, Pinkus GS (1985) Leukocyte common antigen a diagnostic discriminant between hematopoietic and nonhe- matopoietic neoplasms in paraffin sections using monoclonal antibodies: correlation with immunologic studies and ultrastructural localization. Hum Pathol 16: 353–365PubMedCrossRefGoogle Scholar
  36. Lattes R (1962) Thymoma and other tumors of the thymus: an analysis of 107 cases. Cancer 15: 1224v1260Google Scholar
  37. LeGolvan DP, Abell MR (1977) Thymomas. Cancer 39: 2142–2157CrossRefGoogle Scholar
  38. Lemann II, Smith J (1926) Primary carcinoma of the thymus: report of a case. Arch Intern Med 38: 807–815Google Scholar
  39. Leong AS-Y, Brown JH (1984) Malignant transformation in a thymic cyst. Am J Surg Pathol 8: 471–475PubMedCrossRefGoogle Scholar
  40. Levine GD (1973) Primary thymic seminoma: a neoplasm ul- trastructurally similar to testicular seminoma and distinct from epithelial thymoma. Cancer 31: 729–741PubMedCrossRefGoogle Scholar
  41. Levine GD, Bensch KG (1972) Epithelial nature of spindle- cell thymoma: an ultrastructural study. Cancer 30: 500–511PubMedCrossRefGoogle Scholar
  42. Levine GD, Rosai J (1978) Thymic hyperplasia and neoplasia: a review of current concepts. Hum Pathol 9: 495–515PubMedCrossRefGoogle Scholar
  43. Levine GD, Rosai J, Bearman RM, Polliack A (1975) The fine structure of thymoma, with emphasis on its differential diagnosis: a study of ten cases. Am J Pathol 81: 49–86PubMedGoogle Scholar
  44. Leyvraz S, Henle W, Chahinian AP, Perlmann C, Klein G, Gordon RE, Rosenblum M, Holland JF (1985) Association of Epstein-Barr virus with thymic carcinoma. N Engl J Med 312: 1296–1299PubMedCrossRefGoogle Scholar
  45. Lewis JE, Wick MR, Scheithauer BW, Bernatz PE, Unni KK, Taylor WF (1987) Thymoma: a clinicopathologic review. Cancer 60: 2727–2743PubMedCrossRefGoogle Scholar
  46. Lichtenstein AK, Levine A, Taylor CR, Bos well W, Rossman S, Feinstein DI, Lukes RJ (1980) Primary mediastinal lymphoma in adults. Am J Med 68: 509–514PubMedCrossRefGoogle Scholar
  47. Lowenhaupt E (1948) Tumors of the thymus in relation to the thymic epithelial anlage. Cancer 1: 547–563CrossRefGoogle Scholar
  48. Lowenhaupt E, Brown R (1951) Carcinoma of the thymus of granulomatous type: a clinical and pathological study. Cancer 4: 1193–1209PubMedCrossRefGoogle Scholar
  49. Luna MA, Valenzuela-Tamariz J (1976) Germ-cell tumors of the mediastinum: postmortem findings. Am J Clin Pathol 65: 450–454PubMedGoogle Scholar
  50. MacDonald J, Parker JC Jr, Brown S, Page LK, Wolfe DE (1978) Cerebral metastasis from a malignant thymoma. Surg Neurol 9: 58–60PubMedGoogle Scholar
  51. Maggi G, Giaccone G, Donadio M, Ciuffreda L, Dalesio O, Leria G, Trifiletti G, Casadio C, Palestro G, Mancuso M, Calciati A (1986) Thymomas: a review of 169 cases, with particular reference to results of surgical treatment. Cancer 58: 765–776PubMedCrossRefGoogle Scholar
  52. McBurney RP, Clagett OT, McDonald JR (1951) Primary intrapulmonary neoplasm (thymoma?) associated with myasthenia gravis: report of a case. Mayo Clin Proc 26: 345–353Google Scholar
  53. Marino M, Müller-Hermelink HK (1985) Thymoma and thymic carcinoma. Virchows Arch A 407: 119–149CrossRefGoogle Scholar
  54. Marks RD Jr, Wallace KM, Pettit HS (1978) Radiation therapy control of nine patients with malignant thymoma. Cancer 41: 117–119PubMedCrossRefGoogle Scholar
  55. Masaoka A, Monden Y, Nakahara K, Tanioka T (1981) Fol- low-up study of thymomas with special reference to their clinical stages. Cancer 48: 2485–2492PubMedCrossRefGoogle Scholar
  56. Mills SE, Cooper PH, Walker AN, Swanson PE, Wick MR (1987) Large-cell neuroendocrine carcinoma of the lung (abstract). Lab Invest 56: 52AGoogle Scholar
  57. Needles B, Kemeny N, Urmacher C (1981) Malignant thymoma: renal metastases responding to cis-platinum. Cancer 48: 223–226PubMedCrossRefGoogle Scholar
  58. Nickels J, Franssila K (1976) Thymoma metastasizing to ex- trathoracic sites: a case report. Acta Pathol Microbiol Immunol Scand [A] 84: 331–334Google Scholar
  59. Osborn M, Weber K (1983) Tumor diagnosis by intermediate filament typing: a novel tool for surgical pathology. Lab Invest 48: 372–394PubMedGoogle Scholar
  60. Pascoe HR, Miner MS (1976) An ultrastructuralstudy of nine thymomas. Cancer 37: 317–326PubMedCrossRefGoogle Scholar
  61. Penn CRH, Hope-Stone HF (1972) The role of radiotherapy in the management of malignant thymoma. Br J Surg 59: 533–539PubMedCrossRefGoogle Scholar
  62. Rachmaninoff N, Fentress V (1964) Thymoma with metastasis to the brain. Am J Clin Pathol 41: 618–625PubMedGoogle Scholar
  63. Reddick RL, Jennette JC (1983) Immunologic and ultrastructural characterization of the small cell population in malignant thymoma. Hum Pathol 14: 377–380PubMedCrossRefGoogle Scholar
  64. Ringborg U, Henle W, Henle G, Ingimarsson S, Klein G, Silfversward C, Strander H (1983) Epstein-Barr virus-specific sérodiagnostic tests in carcinomas of the head and neck. Cancer 52: 1237–1243PubMedCrossRefGoogle Scholar
  65. Rogers BHG, Manaligod JR, Blazek WV (1968) Thymoma associated with pancytopenia and hypogammaglobulinemia: report of a case and review of the literature. Am J Med 44: 154–164PubMedCrossRefGoogle Scholar
  66. Rosai J (1981) Mediastinum. In: Rosai J (ed) Ackerman’s surgical pathology, vol 1, 6th edn. Mosby, St. Louis, pp 306–311Google Scholar
  67. Rosai J, Higa E (1972) Mediastinal endocrine neoplasm, of probable thymic origin, related to carcinoid tumor: clinicopathologic study of 8 cases. Cancer 29: 1061–1074PubMedCrossRefGoogle Scholar
  68. Rosai J, Levine GD (1976) Tumors of the thymus. In: Atlas of tumor pathology, sec ser, fasc 13. Armed Forces Institute of Pathology, Washington, DCGoogle Scholar
  69. Rosai J, Levine G, Weber WR, Higa E (1976) Carcinoid tumors and oat cell carcinomas of the thymus. Pathol Annu 11: 201–226PubMedGoogle Scholar
  70. Rosai J, Limas C, Husband EM (1984) Ectopic hamartoma- tous thymoma: a distinctive benign lesion of lower neck. Am J Surg Pathol 8: 501–513PubMedCrossRefGoogle Scholar
  71. Rosenberger A, Adler O (1978) Fine needle aspiration biopsy in the diagnosis of mediastinal lesions. AJR 131: 239–242PubMedGoogle Scholar
  72. Sajjad SM, Lukeman JM, Llamas L, Fernandez T (1982) Needle biopsy diagnosis of thymoma: a case report. Acta Cytol (Baltimore) 26: 503–506Google Scholar
  73. Salyer WR, Eggleston JC (1976) Thymoma: a clinical and pathological study of 65 cases. Cancer 37: 229–249PubMedCrossRefGoogle Scholar
  74. Sato Y, Watanabe S, Mukai K, Kodama T, Upton M, Goto M and Shimosato Y (1986) An immunohistochemical study of thymic epithelial tumors. II. Lymphoid componant. Am J Surg Pathol 10: 862–870Google Scholar
  75. Shellito J, Khandekar JD, McKeever WP, Vick NA (1978) Invasive thymoma responsive to oral corticosteroids. Cancer Treat Rep 62: 1397–1400PubMedGoogle Scholar
  76. Shier KJ (1981) The thymus according to Schambacher: medullary ducts and reticular epithelium of thymus and thymomas. Cancer 48: 1183–1199PubMedCrossRefGoogle Scholar
  77. Shimosato Y, Kameya T, Nagai K, Suemasu K (1977) Squamous cell carcinoma of the thymus: an analysis of eight cases. Am J Surg Pathol 1: 109–121PubMedCrossRefGoogle Scholar
  78. Slater G, Papatestas AE, Genkins G, Kornfeld P, Horowitz SH, Bender A (1978) Thymomas in patients with myasthenia gravis. An Surg 188: 171–174CrossRefGoogle Scholar
  79. Sloane JP, Ormerod MG (1981) Distribution of epithelial membrane antigen in normal and neoplastic tissues and its value in diagnostic tumor pathology. Cancer 47: 1786–1795PubMedCrossRefGoogle Scholar
  80. Smith WF, DeWall RA, Krumholz RA (1970) Giant thymoma. Chest 58: 383–385CrossRefGoogle Scholar
  81. Snover DC, Levine GD, Rosai J (1982) Thymic carcinoma: five distinctive histological variants. Am J Surg Pathol 6: 451–470PubMedCrossRefGoogle Scholar
  82. Souadjian JV, Enriquez P, Silverstein MN, Pépin JM (1974) The spectrum of diseases associated with thymoma: coincidence or syndrome? Arch Intern Med 134: 374–379PubMedCrossRefGoogle Scholar
  83. Sterchi M, Cordell AR (1975) Seminoma of the anterior mediastinum. Ann Thorac Surg 19: 371–377PubMedCrossRefGoogle Scholar
  84. Sterrett G, Whitaker D, Shilkin KB, Walters MN-I (1983) The fine needle aspiration cytology of mediastinal lesions. Cancer 51: 127–135PubMedCrossRefGoogle Scholar
  85. Swinborne-Sheldrake K, Gray GF, Glick AD (1985) Thymicepithelial neoplasms. Southern Med J 78: 790–800PubMedCrossRefGoogle Scholar
  86. Symmers D (1932) Malignant tumors and tumor-like growths of the thymic region. Ann Surg 95: 544–572PubMedCrossRefGoogle Scholar
  87. Tanaka M, Shimokawa R, Matsubara O, Aoki N, Kamiyama R, Kasuga T, Hatakeyama S (1982) Mucoepidermoid carcinoma of the thymic region. Acta Pathol Jpn 32: 703–712PubMedGoogle Scholar
  88. Thomson AD, Thackray AC (1957) The histology of tumours of the thymus. Br J Cancer 11: 348–364PubMedCrossRefGoogle Scholar
  89. Van Heerden JA, Harrison EG Jr, Bernatz PE, Kiely JM (1970) Mediastinal malignant lymphoma. Chest 57: 518–529PubMedCrossRefGoogle Scholar
  90. Verley JM, Hollmann KH (1985) Thymoma: a comparative study of clinical stages, histological features and survival in 200 cases. Cancer 55: 1074–1086PubMedCrossRefGoogle Scholar
  91. Wara DW (1981) Thymic hormones and the immune system. Adv Pediatr 28: 229–270PubMedGoogle Scholar
  92. Wick MR, Siegal GP (1980) Primary mediastinal embryonal carcinoma. Minn Med 63: 723–726PubMedGoogle Scholar
  93. Wick MR, Scott RE, Li C-Y, Carney JA (1980) Carcinoid tumor of the thymus: a clinicopathologic report of seven cases with a review of the literature. Mayo Clin Proc 55: 246–254PubMedGoogle Scholar
  94. Wick MR, Nichols WC, Ingle JN, Bruckman JE, Okazaki H (1981) Malignant, predominantly lymphocytic thymoma with central and peripheral nervous system metastases. Cancer 47: 2036–2043PubMedCrossRefGoogle Scholar
  95. Wick MR, Weiland LH, Scheithauer BW, Bernatz PE (1982) Primary thymic carcinomas. Am J Surg Pathol 6: 613–630PubMedCrossRefGoogle Scholar
  96. Wick MR, Swanson PE, Manivel TC (1987) Placental-like alkaline phosphatase reactivity in human tumors. Hum Pathol 18: 946–954PubMedCrossRefGoogle Scholar
  97. Wolfe JT III, Wick MR, Banks PM, Scheithauer BW (1983) Clear cell carcinoma of the thymus. Mayo Clin Proc 58: 365–370PubMedGoogle Scholar
  98. Wood GS, Link M, Warnke RA, Dilley J, Levy R (1984) Panleukocyte monoclonal antibody L3B12: characterization and application to research and diagnostic problems. Am J Clin Pathol 81: 176–183PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Mark R. Wick
  • Juan Rosai

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