Cyclosporine: Chemistry, Structure-Activity Relationships and Mode of Action

Conference paper
Part of the Progress in Clinical Biochemistry and Medicine book series (PCBM, volume 3)


Cyclosporine is a cyclic peptide with a selective immunosuppressive action. One of its 11 amino acids is a novel amino acid, (4R)-4-((E)-2-butenyl-4,N-dimethyl-L-threonine, the preparation of which allowed the synthesis of cyclosporine and specifically modified analogues. Structure-activity relationships emerging from the study of modified cyclosporins suggest that a large portion of the cyclosporine molecule is involved in interactions with its lymphocyte receptor and that this includes amino acids 1, 2, 3 and 11.


Phorbol Myristate Acetate Tolypocladium Inflatum Peptide Ring Hydroxy Aldehyde Cyclosporine Analogue 
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Authors and Affiliations

  1. 1.Preclinical ResearchSandoz LtdBaselSwitzerland

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