Effect of Cerebroventricular Infusion of Vasopressin on Intracranial Pressure, Blood Pressure and Plasma Vasopressin

  • P. Soelberg Sørensen
  • J. A. Gyring

Abstract

Arginine vasopressin (AVP) is present in the cerebrospinal fluid (CSF) of animal and man (Dogterorn et al. 1978, Sorensen et al. 1985). A number of functions have been proposed for AVP as a putative neurotransmitter in the central nervous system, including regulation of brain water permeability (Raichle and Grubb 1978), influence on CSF drainage (Noto et al. 1978), and involvement in the central regulation of the blood pressure (Pittman et al. 1982). Increased concentrations of AVP in CSF have been found in patients with increased intracranial pressure (ICP) (Sorensen et al. 1984) suggesting the possibility of a causal relationship between elevated CSF AVP levels and increased ICP.

Keywords

Permeability Catheter Depression Polyethylene Arginine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barbella YR, Keil LC, Wurpel JND, Severs WB (1983) Cerebrospinal fluid pressure during cerebro-ventricular infusion of angiotensin and vasopressin. Exp Neurol 82: 325–334PubMedCrossRefGoogle Scholar
  2. Doczi T, Szerdhelyi P, Gulya K, Kiss J (1982) Brain water accumulation after central administration of vasopressin. Neurosurgery 11: 402–409PubMedCrossRefGoogle Scholar
  3. Dogterom JTB, Van Vimersma Greidanus TB, De Wied D (1978) Vasopressin in cerebrospinal fluid and plasma of man, dog, and rat. Am J Physiol 234: E463–E467PubMedGoogle Scholar
  4. Gyring JA, Brondsted HE (1984) Repetitive measurements of intracranial pressure in awake rabbits. Acta Physiol Scand 122: 299–305PubMedCrossRefGoogle Scholar
  5. Hammer M (1978) Radio immunoassay of 8-arginine-vasopressin (antidiuretic hormone) in human plasma. Scand J Clin Lab Invest 38: 707–716PubMedCrossRefGoogle Scholar
  6. Noto T, Nakajima T, Saji Y, Nagawa Y (1978) Effect of vasopressin on intracranial pressure of rabbit. Endocrinol Jpn 25: 591–596PubMedCrossRefGoogle Scholar
  7. Pittman QJ, Lawrence D, McLean L (1982) Central effects of arginine vasopressin on blood pressure in rats. Endocrinology 110: 1058–1060PubMedCrossRefGoogle Scholar
  8. Raichle ME, Grubb RL Jr (1978) Regulation of brain water permeability by centrally-released vaso-pressin. Brain Res 143: 191–194PubMedCrossRefGoogle Scholar
  9. Sorensen PS, Gjerris F, Hammer M (1984) Cerebrospinal fluid vasopressin and increased intracranial pressure. Ann Neurol 15: 435–440PubMedCrossRefGoogle Scholar
  10. Sorensen PS, Gjerris A, Hammer M (1985) Cerebrospinal fluid vasopressin in neurological and psychiatric disorders. J Neurol Neurosurg Psychiatry 48: 50–57PubMedCrossRefGoogle Scholar
  11. Zerbe RL, Kirtland S, Faden AI, Feuerstein G (1983) Central cardiovascular effects of mammalian neurohypophyseal peptides in conscious rats. Peptides 4: 627–630PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • P. Soelberg Sørensen
    • 1
  • J. A. Gyring
    • 1
  1. 1.Institute of Medical Physiology APanum InstituteCopenhagenDenmark

Personalised recommendations