Effect of Cerebroventricular Infusion of Vasopressin on Intracranial Pressure, Blood Pressure and Plasma Vasopressin
Arginine vasopressin (AVP) is present in the cerebrospinal fluid (CSF) of animal and man (Dogterorn et al. 1978, Sorensen et al. 1985). A number of functions have been proposed for AVP as a putative neurotransmitter in the central nervous system, including regulation of brain water permeability (Raichle and Grubb 1978), influence on CSF drainage (Noto et al. 1978), and involvement in the central regulation of the blood pressure (Pittman et al. 1982). Increased concentrations of AVP in CSF have been found in patients with increased intracranial pressure (ICP) (Sorensen et al. 1984) suggesting the possibility of a causal relationship between elevated CSF AVP levels and increased ICP.
KeywordsIntracranial Pressure Arginine Vasopressin Intraventricular Infusion Putative Neurotransmitter Awake Rabbit
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