Changes in Electrophysiological and Metabolic Indices of Brain Activity Associated with Elevated Intracranial Pressure and Transtentorial Herniation

  • D. d’Avella
  • P. G. Newlon
  • N. Pandolfo
  • M. Giebel
  • D. P. Becker
  • R. L. Hayes
Conference paper

Abstract

These studies compared metabolic and electrophysiological indices of regional brain function in a model of unilateral transtentorial herniation associated with elevated intracranial pressure (Nagao et al. 1979a; Nagao et al. 1979b). Metabolic assessments of regional brain function employed qualitative applications of the [14C] deoxyglucose ([14C]DG) technique to infer changes in rates of glucose utilization and brain activity in specific brain structures (Sokoloff et al. 1977). Electrophysiological studies employed auditory evoked potentials (AEP’s).

Keywords

Ischemia Polyethylene Rubber Dura Naloxone 

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References

  1. Achor LJ, Starr A (1980a) Auditory brain stem responses in the cat. I. Intracranial and extracranial recordings. Electroencephalogr Clin Neurophysiol 48: 154–173Google Scholar
  2. Achor LJ, Starr A (1980b) Auditory brain stem responses in the cat. II. Effects of lesions. Electroencephalogr Clin Neurophysiol 48: 174–190Google Scholar
  3. Buchwald JD, Huang CM (1975) Far-field acoustic responses: Origins in the cat. Science 189: 382–384Google Scholar
  4. Greenberg RP et al. (1981) Noninvasive localization of brain stem lesions in the cat with multimodality evoked potentials: Correlation with human head injury data. J Neurosurg 54: 740–750PubMedCrossRefGoogle Scholar
  5. Hayes RL et al. (1983) Effects of naloxone on systemic and cerebral responses to experimental concussive brain injury in cats. J Neurosurg 58: 720–728PubMedCrossRefGoogle Scholar
  6. Nagao S, (1979a) Acute intracranial hypertension and auditory brain-stem responses. Part 1: Changes in the auditory brain-stem and somatosensory evoked responses in intracranial hypertension in cats. J Neurosurg 51: 669–676PubMedCrossRefGoogle Scholar
  7. Nagao (1979b) Acute intracranial hypertension and auditory brain-stem responses. Part 2: The effects of brain-stem movement on the auditory brain-stem responses due to transtentorial herniation. J Neurosurg 51: 846–851PubMedCrossRefGoogle Scholar
  8. Sokoloff L et al. (1977) The [14C] deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure and normal values in the conscious and anesthetized albino rat. J Neurochem 8: 897–915CrossRefGoogle Scholar
  9. Welsh FA et al. (1980) Correlation between glucose utilization and metabolite levels during fo cal ischemia in the cat brain. Stroke 11: 79–84PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • D. d’Avella
    • 1
  • P. G. Newlon
    • 2
  • N. Pandolfo
    • 1
  • M. Giebel
    • 2
  • D. P. Becker
    • 2
  • R. L. Hayes
    • 2
  1. 1.Division of NeurosurgeryReggio Calabria City HospitalReggio CalabriaItaly
  2. 2.Division of Neurosurgery, Department of Surgery, Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA

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