The Effects of Gammahydroxybutyrate and Sodium Thiopentone on Intracranial Pressure in Severe Head Injury

  • J. R. S. Leggate
  • N. M. Dearden
  • J. D. Miller
Conference paper

Abstract

Barbiturates have been used in the treatment of raised intracranial pressure (ICP) for more than 10 years (Shapiro et al. 1974; Miller 1979). Doubts have been expressed about their effectiveness. A recent prospective trial of barbiturate therapy versus mannitol therapy suggested that barbiturate therapy was not as effective as mannitol and had more deleterious side effects (Schwartz et al. 1984). More recently shorter acting anaesthetic agents have been advocated because of the side effects and long half-life of barbiturates. Two such drugs, Etomidate and Althesin, have recently been withdrawn from clinical use because of side effects.

Keywords

Neurol Mannitol Barbiturate Thiopentone Etomidate 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Escuret E, Baldy-Moulinier M, Roquefeuil B, Frerebeau P (1979) Acta Neurol Scand 60: 38–39Google Scholar
  2. Miller JD (1979) Ann Neurol 6: 189 - 193PubMedCrossRefGoogle Scholar
  3. Schwartz ML, Tator CH, Rowed DW, Reid SR, Meguro K, Andrews DF (1984) Can J Neurol Sci 11: 434–440PubMedGoogle Scholar
  4. Shapiro HM, Wyte SR, Loeser J (1974) J Neurosurg 40: 90–100PubMedCrossRefGoogle Scholar
  5. Wolfson LI, Sakurada O, Sokoloff L (1977) J Neurochem 29: 777–783PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • J. R. S. Leggate
    • 1
  • N. M. Dearden
    • 1
  • J. D. Miller
    • 1
  1. 1.University Department of Surgical NeurologyWestern General HospitalEdinburghUK

Personalised recommendations