Abstract
The mechanism of the action of steroids on brain edema is not fully understood despite its long history. Recently it has been reported that the beneficial effect of steroids might be attributed to inhibition of edema spread or acceleration of edema resorption (Matsuoka, Hossmann 1981; Hossmann et al. 1983; Fenstermacher et al. 1984; Hartmann et al. 1984). Almost all experimental models of edema must involve the formation process and the resolution process of edema which can not be separated from each other experimentally. Using the direct infusion model of edema, the only model in which one can separate these two processes, the question of whether the effect of steroids is exerted on the resolution process was investigated.
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References
Fenstermacher J, Yen M-H, Wright D, Nakagawa H, Blasberg R, Patlak C (1984) Effects of dexamethasone on local blood-brain transfer of AIB and RISA in traumatic cerebral edema. Presented at the sixth international symposium on bra in edema.
Hartmann A, Czernicki Z, Hossmann K-A, Barbosa-Coutinho LM, Menzel J (1984) Effect of dexamethasone on regional cerebral blood flow and on serum protein extravasation in experimental brain infarcts in monkeys, ibid.
Hirano A, Marmarou A, Nakamura T, Inoue A (1984) The fine structural study of brain response to intracerebral infusion of serum in the cat. ibid.
Hossmann K-A, Huerter T, Oschlies U (1983) The effect of dexamethasone on serum protein extravasation and edema development in experimental brain tumors of cat. Acta Neuropathol (Berl) 60: 223–231
Marmarou A, Tanaka K, Shulman K (1982) An improved gravimetric measure of cerebral edema. J Neurosurg 56: 246–253
Marmarou A, Tanaka K, Shulman K (1982) The brain response to infusion edema: Dynamics of fluid resolution. In Hartmann A, Brock M (eds) Treatment of cerebral edema. Springer-Verlag, Berlin, Heidelberg, New York, p 11–18
Matsuoka Y, Hossmann K-A (1981) Corticosteroid therapy of experimental tumour edema. Neurosurg Rev 4: 185–190
Shapiro WR, Posner JB (1974) Corticosteroid hormones. Effects in an experimental brain tumor. Arch Neurol 30: 217–221
Sternberger LA, Hardy PH Jr, Cuculis JJ, Meyer HG (1970) The unlabeled antibody enzyme method of immunohistochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem 18: 315–333
Yamada K, Bremer AM, West CR (1979) Effect of dexamethasone on tumor-induced brain edema and its distribution in the brain of monkeys. J Neurosurg 50: 361–367
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© 1986 Springer-Verlag Berlin Heidelberg
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Tanaka, K., Ohata, K., Katsuyama, J., Nishimura, S., Marmarou, A. (1986). Effect of Steroids on the Resolution Process of Edema. In: Miller, J.D., Teasdale, G.M., Rowan, J.O., Galbraith, S.L., Mendelow, A.D. (eds) Intracranial Pressure VI. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70971-5_116
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DOI: https://doi.org/10.1007/978-3-642-70971-5_116
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