Effects of Mannitol on Tissue Pressure in Focal Cerebral Ischemia

  • G. P. Schielke
  • J. T. Hoff
  • S. Hatashita
  • D. S. Kim
Conference paper

Abstract

Focal cerebral ischemia increases brain water content and tissue pressure (TP) locally. (1) The gradient of hydrostatic pressure that developes between ischemic and normal brain may be important in subsequent events in and around the ischemic focus. We hypothesized that the increased TP further reduces CBF in the ischemic zone by microvascular compression. In the present study we sought to mannipulate the pressure gradient with mannitol to determine the relationship of TP to CBF and brain water in the ischemic region.

Keywords

Ischemia Syringe Mannitol 

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References

  1. Iannotti F, Hoff JT, Schielke GP (1985) Brain tissue pressure in focal cerebral ischemia. J Neurosurg 62: 83–89PubMedCrossRefGoogle Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • G. P. Schielke
    • 1
  • J. T. Hoff
    • 1
  • S. Hatashita
    • 1
  • D. S. Kim
    • 1
  1. 1.University of MichiganAnn ArborUSA

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