Effects of Mannitol on Tissue Pressure in Focal Cerebral Ischemia
Focal cerebral ischemia increases brain water content and tissue pressure (TP) locally. (1) The gradient of hydrostatic pressure that developes between ischemic and normal brain may be important in subsequent events in and around the ischemic focus. We hypothesized that the increased TP further reduces CBF in the ischemic zone by microvascular compression. In the present study we sought to mannipulate the pressure gradient with mannitol to determine the relationship of TP to CBF and brain water in the ischemic region.
KeywordsMiddle Cerebral Artery Occlusion Focal Cerebral Ischemia Evans Blue Brain Water Content Blood Brain Barrier Integrity
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