The Effect of Monensin on Receptor-Mediated Endocytosis of Asialofetuin and Secretion of Very Low Density Lipoproteins (VLDL) by Cultured Rat Hepatocytes

  • C. A. Drevon
  • A. C. Rustan
  • J. Ø. Nossen
  • T. Berg
Conference paper

Abstract

Monensin is a carboxylic ionophore which is able to abolish ionic gradients across membranes (Pressman, 1976). There are indications that monensin inhibits fluid-phase endocytosis (Wilcox et al., 1982), entry of virus particles into fibroblasts and receptor-mediated endocytosis of LDL (Basu et al., 1981) and asialoglycoproteins (Berg et al., 1983). Monensin may cause swelling of the Golgi cisternae and decrease secretion of procollagen, fibronectin (Uchida et al., 1979) and immunoglo-bulins (Tartakoff and Vasalli, 1977). Certain experiments on endocytosis of epidermal growth factor, β-galactosidase, β2-macroglobulin (Pastan and Willing-ham, 1981), insulin (Posner et al., 1982) and asialofetuin (Debanne et al., 1982) suggest that endosomes are directed to the Golgi complex. Conceivably, endo- and exocytosis might have a common pathway through this membrane system.

Keywords

Glycerol Albumin Triacylglycerol Gentamicin Tria 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • C. A. Drevon
    • 1
  • A. C. Rustan
    • 2
  • J. Ø. Nossen
    • 2
  • T. Berg
    • 3
  1. 1.National Institute of Forensic ToxicologyOsloNorway
  2. 2.Department of PharmacologyInstitute of PharmacyNorway
  3. 3.Institute for Nutrition ResearchUniversity of OsloNorway

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