Abstract
In extra-hepatic cells the LDL receptor activity is strongly reduced after incubation of the cells with LDL [1]. Although in vivo hepatocytes are exposed to physiological concentrations of LDL [2], the liver LDL receptor activity is responsible for the catabolism of the main portion of the total amount of plasma LDL [3]. This suggests that in hepatocytes the LDL receptor activity is regulated differently from that in extra-hepatic cells. We studied the regulation of the LDL receptor activity in the human hepatoma cell line Hep G2. The results are compared with those obtained with fibroblasts.
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© 1986 Springer-Verlag Berlin Heidelberg
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Havekes, L., de Wit, E., Princen, H. (1986). Regulation of LDL Receptor Activity in Human Hepatocytes. In: Greten, H., Windler, E., Beisiegel, U. (eds) Receptor-Mediated Uptake in the Liver. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70956-2_13
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DOI: https://doi.org/10.1007/978-3-642-70956-2_13
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