Overview of the Development of Tumor Markers

  • K. B. Björklund
Conference paper


The first attempt to apply bacteriological serology to the problem of malignant tumors was probably made in 1895 by Richet and Hericourt [1] at the Pasteur Institute in Paris. They immunized a donkey and two dogs with human osteosarcoma tissue and injected the resulting immune sera into patients, with no favorable results. Other attempts followed, and one investigator after another became interested in the search for antigens in cancer cells. Between 1895 and 1911 about 55 papers were published on the subject [2–7]. During the next 10 years, there was little interest in the pursuit of this type of research.


Tumor Antigen Insoluble Residue Immune Seron Circulate Immune Complex Tissue Polypeptide Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • K. B. Björklund
    • 1
  1. 1.Cancer Immunology SectionThe National Bacteriological LaboratorySolna, StockholmSweden

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