Production and Use of Positron-Emitting Test Substances for Tumor Diagnosis
New therapeutic regimes like combinations of radio- or chemotherapy with hyperthermia have given rise to growing interest in methods for the in vivo assessment of tumor physiology and metabolism . These methods usually require the use of radioactive compounds which undergo well-defined processes in the organism. Therefore, the attempt to monitor biologic properties of tumors necessitates considering organic radiopharmaceuticals and, in particular, positron emitters. This paper deals with the application of organic radioagents for the assessment of microcirculation and cellular integrity in tumors, and for therapeutic research.
KeywordsUptake Ratio Surrounding Normal Tissue Tumor Blood Flow Radioactive Compound Anhydrous Ether
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- 1.Reimann RE, Rosen G, Gelbard AS, Benua RS, Yeh SDJ, Laughlin JS (1985) Diagnostic demands in clinical and experimental oncology: application of substrates labeled with positron-emitting radionuclides. In: Knapp WH, Vyska K (eds) Tumor cell physiology and positron emission tomography. Springer, Berlin Heidelberg New York Tokyo, pp 73–85Google Scholar
- 3.Oberdorfer F, Helus F, Maier-Borst W et al (1982) The synthesis of (l-11C)-butanol. Radiochem Radioanal Lett 53:237–252Google Scholar