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Production and Use of Positron-Emitting Test Substances for Tumor Diagnosis

  • W. H. Knapp
Conference paper

Abstract

New therapeutic regimes like combinations of radio- or chemotherapy with hyperthermia have given rise to growing interest in methods for the in vivo assessment of tumor physiology and metabolism [1]. These methods usually require the use of radioactive compounds which undergo well-defined processes in the organism. Therefore, the attempt to monitor biologic properties of tumors necessitates considering organic radiopharmaceuticals and, in particular, positron emitters. This paper deals with the application of organic radioagents for the assessment of microcirculation and cellular integrity in tumors, and for therapeutic research.

Keywords

Uptake Ratio Surrounding Normal Tissue Tumor Blood Flow Radioactive Compound Anhydrous Ether 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Reimann RE, Rosen G, Gelbard AS, Benua RS, Yeh SDJ, Laughlin JS (1985) Diagnostic demands in clinical and experimental oncology: application of substrates labeled with positron-emitting radionuclides. In: Knapp WH, Vyska K (eds) Tumor cell physiology and positron emission tomography. Springer, Berlin Heidelberg New York Tokyo, pp 73–85Google Scholar
  2. 2.
    Knapp WH, Helus F, Oberdorfer F, Layer K, Sinn HJ, Ostertag H, Matzku S (1985) 11 C-butanol for imaging of the blood-flow distribution in tumor-bearing animals. Eur J Nucl Med 10:540–548PubMedCrossRefGoogle Scholar
  3. 3.
    Oberdorfer F, Helus F, Maier-Borst W et al (1982) The synthesis of (l-11C)-butanol. Radiochem Radioanal Lett 53:237–252Google Scholar
  4. 4.
    Knapp WH, Helus F, Sinn H, Ostertag H, Georgí P, Brandeis W-E, Braun A (1984) 13N-L-glutamate uptake in malignancy: its relationship to blood flow. J Nucl Med 25:989–997PubMedGoogle Scholar
  5. 5.
    Knapp WH, Debatin J, Layer K, Helus F, Altmann A, Sinn HJ, Ostertag H (1985) Selective drug-induced reduction of blood flow in tumor transplants. Int J Radiat Oncol Biol Phys 11:1357–1366PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • W. H. Knapp
    • 1
    • 2
  1. 1.Deutsches KrebsforschungszentrumInstitut für NuklearmedizinHeidelberg 1Germany
  2. 2.Institut für NuklearmedizinHerzzentrum NRWBad OeynhausenGermany

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