Binding and Information Transfer in Conformationally Restricted Peptides

  • Victor J. Hruby
  • Mac E. Hadley
Conference paper

Abstract

Many peptide hormones and neurotransmitters (both hereafter referred to as hormones) are short, linear, and highly flexible molecules with conformational properties that are dependent on environment. Such properties might be imagined to be valuable for the purposes for which Nature uses them, namely, as molecular switches and chemical messengers for intercellular communication and control of cellular function. In particular, conformational flexibility could be functionally important in several ways. For example, the different conformational states might be related to a number of biological properties of these peptides including:
  1. 1)

    the ability to recognize and interact with several different cellular receptors;

     
  2. 2)

    the ability to “adjust” to evolutionary changes of receptors and of the peptide itself; and

     
  3. 3)

    the possibility of recognition by different enzymes leading to rapid biodegradation and turnover, etc.

     

Keywords

Biodegradation Trypsin Disulfide Glucagon Oxytocin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Victor J. Hruby
    • 1
  • Mac E. Hadley
    • 1
  1. 1.Departments of Chemistry and General BiologyUniversity of ArizonaTucsonUSA

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