Binding and Information Transfer in Conformationally Restricted Peptides

  • Victor J. Hruby
  • Mac E. Hadley


Many peptide hormones and neurotransmitters (both hereafter referred to as hormones) are short, linear, and highly flexible molecules with conformational properties that are dependent on environment. Such properties might be imagined to be valuable for the purposes for which Nature uses them, namely, as molecular switches and chemical messengers for intercellular communication and control of cellular function. In particular, conformational flexibility could be functionally important in several ways. For example, the different conformational states might be related to a number of biological properties of these peptides including:
  1. 1)

    the ability to recognize and interact with several different cellular receptors;

  2. 2)

    the ability to “adjust” to evolutionary changes of receptors and of the peptide itself; and

  3. 3)

    the possibility of recognition by different enzymes leading to rapid biodegradation and turnover, etc.



Adenylate Cyclase Peptide Hormone Frog Skin Peptide Analog Liver Plasma Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Victor J. Hruby
    • 1
  • Mac E. Hadley
    • 1
  1. 1.Departments of Chemistry and General BiologyUniversity of ArizonaTucsonUSA

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