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Specific Reversible Interactions in Life Processes: Antenna Function of Membranes and Their Regioselective, Conformation Selective and Stereoselective Interactions with Regulatory Peptides

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Design and Synthesis of Organic Molecules Based on Molecular Recognition

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Abstract

Many drugs and regulatory peptides, including hormones and neurotransmitters, exert their biological activity by interacting reversibly with specific receptors on the target cell surface [1]. The few receptors that have been studied in some chemical detail, e.g. the acetylcholine receptor and the insulin receptor, are membrane-associated proteins with strong affinities for their agonists (range of Kd about 10-8 to 10-10 M). The receptor-agonist interaction has been likened to the association of enzymes with their substrates or allosteric effectors [2] and similar molecular recognition mechanisms implied, especially an induced complementary fit that optimizes Van der Waals, hydrogen bond, and Coulomb interactions between receptor and peptide agonist [3]. In particular, receptors for flexible peptides can distinguish between functionally different segments of the peptide chains (domains) [4]. Such segments are called message (responsible for triggering the receptor response) and address (responsible for selecting receptor types).

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Authors and Affiliations

  1. Institute for Molecular Biology and Biophysics, Swiss Federal Institute of Technology, CH-8093, Zürich, Switzerland

    Robert Schwyzer

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  1. Robert Schwyzer
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  1. Fakulteit der Wetenschappen, Organische Chemie, Vrije Universiteit Brussels, Pleinlaan 2, B-1050, Brussels, Belgium

    Georges Van Binst

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© 1986 Springer-Verlag Berlin Heidelberg

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Schwyzer, R. (1986). Specific Reversible Interactions in Life Processes: Antenna Function of Membranes and Their Regioselective, Conformation Selective and Stereoselective Interactions with Regulatory Peptides. In: Van Binst, G. (eds) Design and Synthesis of Organic Molecules Based on Molecular Recognition. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70926-5_2

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  • DOI: https://doi.org/10.1007/978-3-642-70926-5_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70928-9

  • Online ISBN: 978-3-642-70926-5

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