Cadmium pp 195-280 | Cite as

Cadmium and the Cardiovascular System

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 80)


The dedication of an entire chapter to the subject of the cardiovascular actions of cadmium implies that cadmium exhibits some degree of selectivity for cardiovascular tissues. Hypothetically, this tissue specificity may be benign or induce changes in the functional properties of these tissues that are biologically significant. This latter assertion is substantiated by the numerous articles published on this subject, particularly those which have demonstrated that chronic exposure to cadmium leads to considerable derangements in cardiovascular system function in humans and experimental animals (Adamska-Dyneewska et al. 1980 a; Boscolo et al. 1980, 1981; Dotta and Fruscella 1963; Iannaccone et al. 1979, 1981; Kopp et al. 1978c, 1980a-d, 1982, 1983a, b; Perry et al. 1977; Perry and Erlanger 1981; Ponteva et al. 1979; Revis et al. 1980, 1983; Revis and Zinsmeister 1981; Schroeder and Vinton 1962; Sturkie 1973; Tomera and Harakal 1980; Vorobieva and Eremeeva 1980). Before describing the cardiovascular actions of cadmium and the putative cellular sites and mechanisms believed to be involved in these effects, a brief discourse summarizing the intrinsic and extrinsic factors that influence and regulate the complex and highly integrated function of the circulatory system is deemed appropriate.


Cadmium Concentration Cadmium Exposure Extracellular Calcium Concentration Aortic Strip Blood Cadmium Level 
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