Cadmium pp 363-396 | Cite as

Cellular Resistance to Cadmium

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 80)


This chapter focuses on the application of cultured cell systems to the study of cellular responses associated with exposure to Cd2+. The scope of this review is limited to considerations of cellular metabolism of Cd2+ and the physiologic and genetic factors that modulate cadmium toxicity. Major emphasis is directed toward three areas: (a) the isolation or derivation of cells differing in Cd2+ cytotoxic response and utilization of such cells to define factors that play a role in cadmium resistance; (b) a consideration of the manifold environmental/physiologic conditions that affect cellular responses in culture; and (c) an evaluation of studies employing somatic cell and molecular genetic techniques to dissect in detail the molecular components of the response mechanisms. The chapter concludes with a discussion of directions and approaches to be pursued in the future to fill gaps in our current understanding of Cd2+ metabolism.


Culture Cell System Chinese Hamster Cell Thymidine Kinase Gene Hypomethylating Agent Human Blood Cell 
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