Abstract
Because of the technical advantages associated with its small size and well known genetics, Drosophila is an excellent model for gerontological research. Further, since the Drosophila imago only contains fixed postmitotic cells, it is very suitable for study of the intricate relationships between cell differentiation and aging. Indeed, as noted elsewhere (Miquel and Fleming 1984), the cyto-logical homogeneity of the fruit fly is a great advantage for the elucidation of the fundamental mechanisms of aging, which are very hard to pinpoint in the complex mammalian tissues.
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References
Andrew W (1964) Changes in the nucleus with advancing age of the organism. Adv Gerontol Res 1:87–107
Anton-Erxleben F, Miquel J, Philpott DE (1983) Fine structural changes in the midgut of old Drosophila melanogaster. Mech Ageing Dev 23:265–276
Atlan H, Miquel J, Heimle LC, Dolkas CB (1976) Thermodynamics of aging in Drosophila melanogaster. Mech Ageing Dev 3:371–387
Donato H, Sohal RS (1978) Age-related changes in lipofuscin associated fluorescent substances in the adult male housefly Musca domestica. Exp Gerontol 12:171–179
Fleming JE, Miquel J (1983) Effects of temperature on the metabolic rate of young and old Drosophila. Experientia 39:267–268
Fleming JE, Leon HA, Miquel J (1981) Effects of ethidium bromide on development and aging of Drosophila: implications for the free radical theory of aging. Exp Gerontol 16:287–293
Fleming JE, Miquel J, Cottrell SF, Yengoyan LS, Economos AC (1982) Is cell aging caused by respiration-dependent injury to the mitochondrial genome? Gerontology 28:44–53
Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11:298–300
Herman MM, Miquel J, Johnson M (1971) Insect brain as a model for the study of aging. Age related changes in Drosophila melanogaster. Acta Neuropathol (Berlin) 19:167–183
Johnson J, Miquel J (1979) Senescent changes in the ribosomes of animal cells in vivo and in vitro. Mech Ageing Dev 8:1–20
Lansing AI (1964) Age variations in cortical membranes of rotifers. J Cell Biol 23:403–424
McArthur MC, Sohal RS (1981) Relationship between metabolic rate, aging, lipid peroxidation and fluorescent age pigment in milkweed bug, Oncopeltus fasciatus (Hemiptera). J Gerontol 37:268–274
Minot CS (1907) The problem of age, growth and death. Pop Sci Mon 71:496
Miquel J (1971) Aging of male Drosophila melanogaster. histological, histochemical and ultra-structural observations. In: Strehler BL (ed) Advances in gerontological research, vol. 3. Academic Press, London New York, pp 39–71
Miquel J, Fleming JE (1984) A two-step hypothesis on the mechanisms of in vitro cell aging: cell differentiation followed by intrinsic mitochondrial mutagenesis. Exp Gerontol 19:31–36
Miquel J, Calvo W, Rubinstein LJ (1968) A simple and rapid stain for the biopsy diagnosis of brain tumors. J Neuropathol Exp Neurol 27:517–523
Miquel J, Bensch KG, Philpott DE (1972) Virus-like particles in the tissues of normal and γ-irradiated Drosophila melanogaster. J Invertebr Pathol 19:156–159
Miquel J, Tappel A, Dillard CJ, Herman MM, Bensch KG (1974) Fluorescent products and lysosomal components in aging Drosophila melanogaster. J Gerontol 29:622–637
Miquel J, Lundgren PR, Bensch KG (1975) Effects of oxygen-nitrogen (1:1) at 760 Torr on the life span and fine structure of Drosophila melanogaster. Mech Ageing Dev 4:41–57
Miquel J, Lundgren PR, Bensch KG, Atlan H (1978) Effects of temperature on the life span and fine structure of Drosophila melanogaster. Mech Ageing Dev 5:347–370
Miquel J, Economos AC, Bensch KG, Atlan H, Johnson JE Jr (1979) Review of cell aging in Drosophila and mouse. Age 2:78–88
Miquel J, Economos AC, Fleming J, Johnson JE Jr (1980) Mitochondrial role in cell aging. Exp Gerontol 15:575–591
Miquel J, Economos AC, Bensch KG (1981) Insect vs. mammalian aging. In: JE Johnson Jr (ed) Aging and cell structure, vol. 1. Plenum Publ, New York, pp 347–379
Miquel J, Fleming JE, Economos AC (1982) Antioxidants, mitochondrial respiration and aging in Drosophila. Arch Gerontol Geriatr 1:349–363
Miquel J, Binnard R, Fleming JE (1983) Role of metabolic rate and DNA repair in Drosophila aging: implications for the mitochondrial mutation theory of cell aging. Exp Gerontol 18:161–171
Miquel J, Economos AC, Johnson JE Jr (1984) A systems-thermodynamic view on cell and organismic aging. In: Johnson JE (ed) Aging and cell function. Plenum Press, New York London, pp 247–280
Pearl R (1928) The rate of living. Univ London Press, London
Sohal RS (1981a) Relationship between metabolic rate, lipofuscin accumulation and lysosomal enzyme activity during aging in the adult house fly, Musca domestica. Exp Gerontol 16:347–355
Sohal RS (1981b) Metabolic rate, aging and lipofuscin accumulation. In: Sohal RS (ed) Age pigments. Elsevier/North Holland, Amsterdam, pp 303–316
Sohal RS, Allison VF (1971) Age related changes in the fine structure of the flight muscle in the house fly. Exp Gerontol 6:167–172
Spoerri PE, Glees P (1973) Neuronal aging in cultures: an electron microscope study. Exp Gerontol 8:259–263
Strehler BL (1977) Time, cells and aging. Academic Press, London New York, pp 307–324
Takahashi A, Philpott DE, Miquel J (1970) Electron microscope studies on aging Drosophila melanogaster. III. Flight muscle. J Gerontol 25:222–228
Wallach Z, Gershon D (1974) Altered ribosomal particles in senescent nematodes. Mech Ageing Dev 3:225–234
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© 1986 Springer-Verlag Berlin Heidelberg
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Miquel, J., Philpott, D.E. (1986). Structural Correlates of Aging in Drosophila: Relevance to the Cell Differentiation, Rate-of-Living and Free Radical Theories of Aging. In: Collatz, KG., Sohal, R.S. (eds) Insect Aging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70853-4_9
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DOI: https://doi.org/10.1007/978-3-642-70853-4_9
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