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Influence of Subminimal Inhibitory Concentrations of Antibiotics on Antigen Expression and Metabolic Activity of Salmonella Species

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Book cover The Influence of Antibiotics on the Host-Parasite Relationship II

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Abstract

Subminimal inhibitory concentrations (subMICs) of antibiotics may induce changes in bacterial morphology, ultrastructure, biochemistry and in multiplication rate [15,19,21,22,23,26,31,36]. SubMICs of antibiotics may also increase susceptibility to phagocytosis and intracellular killing [8,9,30], or affect the ability of bacteria to adhere to epithelial cells [1,34]. Considering that the morphological and structural changes produced by subMICs of antibiotics are different from those induced by ≧ MICs, Lorian [19] postulated that the biochemical changes responsible for them must also be significantly different. It should, therefore, be expected that bacteria exposed to subMICs of antibiotics show also alterations in antigen expression with changes in their pathogenicity and the related immune response.

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Authors and Affiliations

  1. Department of Medical Microbiology, Medical Faculty, Pauwelsstraße, 5100, Aachen, Germany

    G. Gillissen & B. Melzer

Authors
  1. G. Gillissen
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  2. B. Melzer
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Editor information

Editors and Affiliations

  1. Kinderklinik der Universität München, Lindwurmstraße 4, 8000, München 2, Germany

    Dieter Adam

  2. Institut für Medizinische Mikrobiologie, Freie Universität Berlin, Hindenburgdamm 27, 1000, Berlin 45, Germany

    Helmut Hahn

  3. Abteilung für Theoretische und Klinische Medizin, Ruhr-Universität Bochum, Universitätsstraße 150, 4630, Bochum 1, Germany

    Wolfgang Opferkuch

  4. Lehrstuhl für Medizinische Mikrobiologie und Immunologie, Ruhr-Universität Bochum, Universitätsstraße 150, 4630, Bochum 1, Germany

    Wolfgang Opferkuch

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© 1985 Springer-Verlag Berlin Heidelberg

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Gillissen, G., Melzer, B. (1985). Influence of Subminimal Inhibitory Concentrations of Antibiotics on Antigen Expression and Metabolic Activity of Salmonella Species. In: Adam, D., Hahn, H., Opferkuch, W. (eds) The Influence of Antibiotics on the Host-Parasite Relationship II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70748-3_9

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  • DOI: https://doi.org/10.1007/978-3-642-70748-3_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70750-6

  • Online ISBN: 978-3-642-70748-3

  • eBook Packages: Springer Book Archive

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