Protection of tracheal explants infected with Pseudomonas aeruginosa by subinhibitory concentrations of aminoglycosides
Mortality rates for acute pneumonias caused by Pseudomonas aeruginosa may exceed 50%  and antibiotic therapy remains a difficult problem. Therapy frequently includes administration of an aminoglycoside alone or in combination with a beta-lactam antibiotic. Animal studies have shown that gentamicin or tobramycin were superior to carbenicillin or ticarcillin in controlling experimental Pseudomonas pneumonia . Observations have also been made in cystic fibrosis (CF) patients with chronic P. aeruginosa lung infections which indicated that the lung functions of these patients improved following therapy with aminoglycoside antibiotics although the organisms were not cleared . It seemed possible, therefore, that aminoglycoside antibiotics could prevent lung damage by a mechanism that did not involve inhibition of bacterial growth.
KeywordsPneumonia Pseudomonas Glycoside Gentamicin Tray
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- 2.Beachey EH, Eisenstein BI, Ofek I (1981) Sublethal antibiotics and bacterial adhesion. In: Adhesion and micro-organism pathogenicity (Ciba Foundation Symposium 80 ), Tunbridge Wells, London pp 288–300Google Scholar
- 4.Dalhoff A, Doring G (1984) Effect of ciprofloxacin on the expression of exoenzymes and exotoxin of P. aeruginosa. Abstr 24th Intersci Conf Antimicro Agents Chemother abstr no 981, pg 263Google Scholar
- 5.Dalhoff A, Doring G, Goldstein W (1984) Comparative antibacterial activity of ciprofloxacin, ß-lactams and aminoglycosides against P. aeruginosa. In: Lawson D (ed) Cystic Fibrosis: Horizons Proc 9th Internat Cystic Fibrosis Congress, p 289 John Wiley & Sons, Chichester, EnglandGoogle Scholar
- 6.Glew RH, Pavuk RA (1984) Early synergistic interactions between amikacin and six ß-lactam antibiotics against multiply resistant members of the family Enterobacteriaceae. Antimicrob Agents Chemother 26: 78–381Google Scholar
- 9.Hoiby N (1984) The management of Pseudomonas chest infection-the way forward. In: Lawson D (ed) Cystic Fibrosis: Horizons Proc 9th Internat Cystic Fibrosis Congress, pp 87–95 John Wiley & Sons, Chichester, EnglandGoogle Scholar
- 10.Lorian V (1980) Effects of subminimum inhibitory concentrations of antibiotics on bacteria, pp 342–408. In: Lorian V (ed) Antibiotics in laboratory medicine. The Williams & Wilkins Co, BaltimoreGoogle Scholar
- 15.Warren RL, Baker NR, Johnson J, Stapleton MH (1985) Aminoglycosides selectively inhibit the accumulation of extracellular proteases of Pseudomonas aeruginosa. Antimicrob Agents Chemoth (in press April 1985)Google Scholar