Abstract
Treatment of bacterial infections with antibiotics is only succesful if host defence mechanisms, especially phagocytosis and intracellular killing, are effective. Recent reports have provided evidence that subinhibitory concentrations of β-lactam antibiotics can change bacterial morphology and surface composition as well as the adherence properties of the bacteria to phagocytes (Leying et al., in press, 1985, and Leying, this volume; [1,5,8]). The question now arises whether these changes are of any influence on the phagocytosis and killing of the bacteria by these cells. In the present study the influence of β-lactam antibiotics on the attachment and killing of the bacteria by macrophages was investigated. The quantitation of bacteria in this study was done by determining bacterial cell masses.
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© 1985 Springer-Verlag Berlin Heidelberg
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Pawelzik, M., Wiemer, C., Büscher, K.H., Opferkuch, W. (1985). The Effect of Antibiotics on the Killing of E. Coli by Macrophages of the Cell Line P 388 D1. In: Adam, D., Hahn, H., Opferkuch, W. (eds) The Influence of Antibiotics on the Host-Parasite Relationship II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70748-3_14
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DOI: https://doi.org/10.1007/978-3-642-70748-3_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70750-6
Online ISBN: 978-3-642-70748-3
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