Susceptibility to Abelson or Moloney Murine Leukemia Viruses
The differential susceptibilities of inbred mice to tumor development have provided systems to study some of the host cell genes that control these complex processes. In the case of genes that control susceptibility to exogenous tumor viruses several levels of host susceptibility are possible. These include infection of appropriate tissues, transformation of susceptible tissues, and immunological responses to infected or transformed cells. Although there is evidence that each may be the basis of action for some host susceptibility genes; in no case is there sufficient evidence for molecular models of how host susceptibility genes work.
KeywordsMurine Leukemia Virus Tumor Induction Recombinant Inbred Strain Helper Virus Host Cell Gene
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