Abstract
Picornaviruses are important human pathogens. They infect a number of different tissues and cause a variety of diseases. The most notable human pathogens are the polio, coxsackie and echo viruses which have been implicated in insulin-dependent diabetes, myocarditis, hepatitis, orchitis, meningitis and encephalitis (Curnen, 1979; Freeman, 1985; Ginsberg and Dulbecco, 1980; Huber and MacPherson, 1984). Picornaviruses are ubiquitous and most of us develop antibodies to a number of the members of this group (Lerner et al, 1975). Usually, the viruses induce either asymptomatic or mild febrile illnesses, but they also produce life-threatening diseases in a small number of infected individuals (Freeman, 1979). Various factors influence the severity of the infection and the degree of tissue involvement including the age and genetic constitution of the individual, the concentration and variant of the virus and the physiological state of the host (Craighead, 1981; Cudworth and Wolf, 1983; Naji et al., 1983; Woodruff, 1980). Animal models are useful in identifying host genetic factors controlling viral pathogenicity. The M variant of encephalomyocarditis (EMC) virus infects the pancreas, heart and brain of mice and causes diabetes, myocarditis and paralysis. As shown in this report, tissue damage results from T cell mediated autoimmunity rather than from virus mediated injury. Additionally, Balb/cCUM and Balb/cBYJ mice differ strikingly in susceptibility to these autoimmune diseases.
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References
Appel MC, Rossini AA, Williams RM, Like AA (1978) Viral studies in streptozotocin-induced pancreatic insulitis. Diabetologia 15:327–336.
Boucher DW, Notkins AL (1973) Virus-induced diabetes mellitus. I. Hyperglycemia and hypoinsulinemia in mice infected with encephalomyocardits virus. J Exp Med 137:1226–1239.
Craighead JE (1965) Some properties of the encephalomyocarditis, Columbia SK and Mengo viruses. Proc Soc Exp Biol Med 119: 408–412.
Craighead JE (1966) Pathogenecity of the E and M variants of the encephalomyocarditis (EMC) virus. II. Lesions of the pancreas, parotid and lacrimal glands. Am J Pathol 48: 375–386.
Craighead JE, Steinke J (1971) Diabetes mellitus-like syndrome in mice infected with encephalomyocarditis virus. Am J Pathol 63:1 19–134.
Craighead JE, Kanich RE, Kessler JB (1974) Lesions of the islets of Langerhans in encephalomyocarditis virus-infected mice with diabetes mellitus-like syndrome. Am J Pathol 74:287–294.
Craighead JE (1975) The role of viruses in the pathogenesis of pancreatic disease and diabetes mellitus. Prog Med Virol 19:161–214.
Craighead JE (1981) Viral diabetes mellitus in man and experimental animals. Am J Med 70:127–134.
Cudworth AC, Wolf E (1983) Immunology of clinical and experimental diabetes. Plenum Medical Book Co, New York, p 271.
Curnen EC (1979) Textbook of Pediatrics. WB Saunders, Philadelphia, p 914.
Defoe DC, Naji A, Plotkin SA, Barker CF (1980) Susceptibility to diabetogenic virus: Host versus pancreatic factors. J Surg Res 28:338–347.
Freeman BA (1985) Burrows Textbook of Microbiology. WB Saunders, Philadelphia, p 812.
Ginsberg HS, Dulbecco R (1980) Microbiology. Harper & Row, Hagerstown, p 967.
Huber SA, MacPherson BR (1983) Immunology of clinical and experimental diabetes. Plenum Medical Book Co, New York, p295.
Jansen FK, Thurneyssen O, Muntefering H (1979) Virus induced diabetes and the immune system. II. Evidence for an immune pathogenesis of the acute phase of diabetes. Biomedicine 31:1–2.
Like AA, Rossini, AA (1976) Streptozotocin-induced pancreatic insulitis: New model of diabetes mellitus. Science 193:415–417.
Leiter E (1985) This journal
Lerner AM, Wilson FM, Reyes MP (1975) Enteroviruses and the heart (with special emphasis upon the probable role of coxsackieviruses, group B, types 1–5). I. Epidemiological and experimental studies. Mod Concepts Cardiovasc Dis 44:7–10.
Muntefering H, Jansen FK (1984) Immunology of clinical and experimental diabetes. Plenum Medical Book Co. New York, p 73.
Murnane TG, Craighead JE, Mondragon H, Shelokov A (1960) Fatal disease of swine due to encephalomyocarditis virus. Science 131: 498–499.
Naji A, Silvers WK, Barker CF (1983) Autoimmunity and type I (insulin-dependent) diabetes mellitus. Transpl 36:355–361.
Potter M, Wax JS (1981) Genetics of susceptibility to pristane-induced plasmacytomas in Balb/cAn: Reduced susceptibility in Balb/cJ with a brief description of pristane-induced arthritis. J Immunol 127:1591–1595.
Rossini AA, Like AA, Chick WL, Appel MC, Cahill CF (1977) Studies of streptozotocin induced insulitis and diabetes. Proc Natl Acad Sci USA 74:2485–2489.
Woodruff JF (1980) Viral myocarditis: A review. Am J Pathol 101:425–484.
Woodruff JF, Kilbourne ED (1970) The influence of quantitated post-weaning undernutrition on coxsackievirus B-3 infection of adult mice. I. Viral persistence and increased severity of lesions. J Infect Dis 121:137–163.
Yoon JW, Notkins AL (1976) Virus induced diabetes mellitus. VI. Genetically determined host differences in the replication of encephalomyocarditis virus in pancreatic beta cells. J Exp Med 143:1170–1185.
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Babu, P.G., Huber, S., Sriram, S., Craighead, J.E. (1985). Genetic Control of Multisystem Autoimmune Disease in Encephalomyocarditis Virus Infected BALB/cCUM and BALB/cBYJ Mice. In: Potter, M. (eds) The BALB/c Mouse. Current Topics in Microbiology and Immunology, vol 122. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70740-7_23
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DOI: https://doi.org/10.1007/978-3-642-70740-7_23
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