Role of T Cells in the Unusual Cutaneous Responses to Leishmania in BALB/c Mice
Understanding of the major influence of host immunogenetics on leishmaniasis has been greatly advanced by the use of inbred mouse strains which are susceptible to leishmanial species pathogenic to man. Most inbred mice are relatively resistant to cutaneous leishmaniasis and develop limited self-healing or non-progressive lesions. In contrast, BALB/c mice are extremely susceptible to Leishmania major which produces uniformly fatal disseminating visceral disease even with minimal infecting doses. Evidence will be summarised showing that the idiosyncratic response of BALB/c mice to cutaneous leishmaniasis is determined by a series of interactions between various subsets of specific T cells, the balance of which determines the outcome of infection.
KeywordsCutaneous Leishmaniasis Major Infection Cell Surface Phenotype Sublethal Irradiation Leishmania Tropica
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