Abstract
There is universal agreement among protozoologists working with Leishmania that the BALB/c mouse is especially susceptible to infection with these reticuloendothelial cell pathogens. A random survey of mouse strain distributions for susceptibility to different Leishmania species suggests that the BALB/c may be unique in this regard: it is the only reported strain that is susceptible to both cutaneous and visceral leishmaniases (Bradley 1977; DeTolla, Scott & Farrell 1981; Howard, Hale & Chan-Liew 1980; Perez, Arredondo & Gonzalez 1978). The genetics of innate resistance to one of the visceral leishmanias, L. donovani, has been analyzed in detail (Bradley, Taylor, Blackwell, Evans & Freeman 1979): early control of intrahepatic replication of the parasite is regulated in intravenously (iv) inoculated mice by a gene on chromosome 1, Lsh. This gene, or a cluster of tightly linked genes, controls early resistance of mice to several distinctly different intracellular pathogens: Salmonella typhimurium (Plant & Glynn 1976; Taylor & O’Brien 1982;) Mycobacterium bovis (BCG) (Gros, Skamene & Forget 1981), M. lepraemurium (Skamene, Gros, Forget, Patel & Nesbitt 1984); and M. intracellulare (Goto, Nakamura, Takahashi & Tokunaga 1984); and L. donovani (Bradley et al. 1979).
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© 1985 Springer-Verlag Berlin Heidelberg
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Mock, B.A., Fortier, A.H., Potter, M., Blackwell, J., Nacy, C.A. (1985). Genetic Control of Systemic Leishmania major Infection: Identification of Subline Differences for Susceptibility to Disease. In: Potter, M. (eds) The BALB/c Mouse. Current Topics in Microbiology and Immunology, vol 122. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70740-7_17
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DOI: https://doi.org/10.1007/978-3-642-70740-7_17
Publisher Name: Springer, Berlin, Heidelberg
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