Immunoprophylaxis in BALB/c Mice: A Model for Development of Protection Against Primary and Secondary Infection with Leishmania major

  • B. A. Mock
  • A. H. Fortier
  • M. S. Meltzer
  • C. A. Nacy
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 122)


BALB/c mice develop both nonhealing cutaneous lesions and fatal systemic disease following subcutaneous (sc) inoculation of the protozoan parasite, Leishmania major. Several interesting features characterize this fulminant infection, and set BALB/c mice apart from other susceptible strains: (1) fatal disease in the BALB/c is virtually independent of infective parasite dose (Howard, Hale & Chan-Liew 1980), (2) a macrophage defect(s) appears to underlie the innate susceptibility of BALB/c mice to this strain of Leishmania (Behin, Mauel & Sordat 1979; Handman, Ceredig & Mitchell 1979; Nacy, Fortier, Pappas & Henry 1983; Mitchell, Anders, Brown, Handman, Roberts-Thomson, Chapman, Forsyth, Kahl & Cruise 1982) and (3) immunosuppression attributed to either lymphocytes (Howard, Hale & Liew 1980) or macrophages (Scott & Farrell 1981) develops in the later stages of infection, possibly the net result of vigorous parasite proliferation in defective macrophages.


Cutaneous Leishmaniasis Popliteal Lymph Node Nonspecific Resistance Leishmania Amastigotes Alloxan Monohydrate 
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© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • B. A. Mock
  • A. H. Fortier
  • M. S. Meltzer
  • C. A. Nacy

There are no affiliations available

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