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Paget’s Disease of Bone (Osteitis deformans)

  • J. R. Shapiro
Conference paper

Abstract

Sir James Paget presented five cases illustrating a chronic, slowly progressive and disabling bone disorder to the Medical and Chirurgical Society of London on November 14, 1876 (Handy, 1981). A century later, we are able to apply medical therapy which slows the progress of the disease in many patients but cures none. The etiology of Paget’s disease remains obscure, although recent evidence suggests (but does not prove), that its cause is a putative viral infection of skeletal osteoclasts.

Keywords

Bone Turnover Respiratory Syncytial Virus Measle Virus Salmon Calcitonin Serum Osteocalcin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Alexandre: Personal CommunicationGoogle Scholar
  2. 2.
    Barker, D.J., Chamberlain, A.T., Guyer, P.B., Gardner, M.J.: Paget’s disease of bone in 14 British towns. Brit.Med.J. 1, 1181, 1981.CrossRefGoogle Scholar
  3. 3.
    Bijvoet, O.L.M.: Bisphosphonate treatment for Paget’s disease of bone. In, Clinical Disorders of Bone and Mineral Metabolism. Eds: Frame, B. and Potts, J.T. Excerpta Medica, Amsterdam, 1984. pp 389–393.Google Scholar
  4. 4.
    Bijvoet, O.L.M., Frijlink, W.B., et al: APD in Paget’s disease of bone. Arthritis Rheum. 23, 1193, 1980.PubMedCrossRefGoogle Scholar
  5. 5.
    de Deuxchaisnes, C.N.: Do calcitonins help Paget’s disease. In, Clinical Disorders of Bone and Mineral Metabolism. Eds: Frame,B. and Potts, J.T. Excerpta Medica, Amsterdam, 1984. pp 384–388.Google Scholar
  6. 6.
    de Deuxchaisnes, et al: Therapeutic regimens in Paget’s disease of bone. Arthritis Rheum. 23_, 1225, 1980.Google Scholar
  7. 7.
    Frijlink, W.B., TeVelde, J., Bijvoet, O.L., and Heynen, G.: Treatment of Paget’s disease with (3-amino-l-hydroxypropylidene)-1, bisphosphonate (APD). Lancet 1, 799, 1979.PubMedCrossRefGoogle Scholar
  8. 8.
    Gherardi, G., Lo Cascio, V., and Bonucci, E.: Fine structure of nuclei and cytoplasm of osteoclasts in Paget’s disease of bone. Histopathology 4, 63, 1981.CrossRefGoogle Scholar
  9. 9.
    Gundberg, C.M., Lian, J.B., Gallop, P.M., and Steinberg, J.J.: Urinary gamma carboxyglutamic acid and serum osteocalcin as bone markers: Studies in osteoporosis and Paget’s disease. J.Clin.Endo.Metab. 57, 1221, 1983.CrossRefGoogle Scholar
  10. 10.
    Handy, R.C.: Paget’s Disease of Bone. Assessment and Management. Praeger Publ., Great Britain, 1981.Google Scholar
  11. 11.
    Howatson, A.F. and Fornasier, V.L.: Microfilaments associated with Paget’s disease of bone: Comparison with nucleocapsids of measles virus and respiratory syncytial virus. Intervirology 18, 151, 1982.CrossRefGoogle Scholar
  12. 12.
    Johnston, C.C., Altman, R.D., Canfield, R.E., Finerman, G.A.M., Taulbee, J.D., and Ebert, M.L.: Review of fracture experience during treatment of Paget’s disease of bone with etidronate disodium (EHDP). Clin. Orthop. 172, 186, 1983.PubMedGoogle Scholar
  13. 13.
    Krane, S.M., Kantrowitz, F.G., Byrne, M., Pinnell, S.R., and Singer, F.R.: Urinary excretion of hydroxylysine and its glycosides as an index of collagen degradation. J.Clin.Invest. 59, 819, 1977PubMedCrossRefGoogle Scholar
  14. 14.
    MacIntyre, I., Evans, I.M., Hobitz, M.H.G., Joplin, G.F., and Stevenson, J.C.: Chemistry, physiology and therapeutic applications of calcitonin. Arthritis Rheum. 23, 1139, 1980PubMedCrossRefGoogle Scholar
  15. 15.
    Mautalen, C.A.: Treatment of Paget’s bone disease with bisphosphonate APD. Henry Ford Hosp.Med.J. 31, 244, 1983.PubMedGoogle Scholar
  16. 16.
    Merkow, R.L. and Lane, J.M.: Current concepts of Paget’s disease of bone. Ortho.Clin.N.A. 15, 747, 1984Google Scholar
  17. 17.
    Mills, B. and Singer, F.: Nuclear inclusions in Paget’s disease of bone. Science 194, 211, 1976.CrossRefGoogle Scholar
  18. 18.
    Mills, B.G., Singer, F.R., Weiner, L.P., and Hoist, P.A.: Immunohistological demonstration of respiratory syncytial virus antigens in Paget’s disease of bone. Proc.Nat.Acad.Sci. 78, 1219, 1981.CrossRefGoogle Scholar
  19. 19.
    Mills, B.G., Singer, F.R., Weiner, L.P., Suffin, S.C., Stabile, E., and Hoist, P.: Evidence for both respiratory syncytial virus and measles virus antigens in the osteoclasts of patients with Paget’s disease of bone. Clin. Orthop. 183, 313, 1984.Google Scholar
  20. 20.
    Mulivor, R.A., Boccelli, D., and Harris, H.: Quantitative analysis of alkaline phosphatases in serum and amniotic fluid: Comparison of biochemical and immunologic assays. J. Lab. Clin. Med. 115, 342, 1985.Google Scholar
  21. 21.
    Niell, H.B., Palmieri, G.M., Neely, C.L., and McDonald, M.W.: Postabsorptive urinary hydroxyproline test in patients with metastatic bone disease from breast cancer. Arch. Int. Med. 141, 1471, 1981.CrossRefGoogle Scholar
  22. 22.
    Perry, H.M., Droke, D.M., and Avioli, L.V.: Alternate calcitonin and etidronate disodium therapy for Paget’s bone disease. Arch. Int. Med. 144, 929, 1984.CrossRefGoogle Scholar
  23. 23.
    Revel, A., Bregeon, C., Basle, M., and Malkani, K.: Is Paget’s bone disease a viral infection? Calcif. Tiss. Res. 22, 283, 1975.Google Scholar
  24. 24.
    Ryan, W.G.: Pathophysiology and modern management of Paget’s disease. Compreh. Therapy 9, 64, 1983.Google Scholar
  25. 25.
    Ryan, W.G. and Schwartz, T.B.: Mithramycin treatment of Paget’s disease of bone. Arthr. Rheum. 23, 1155, 1980.CrossRefGoogle Scholar
  26. 26.
    Simon, L.S., Krane, S.M., Wortman, P.D., Krane, I.M., and Kovitz, K.L.: Serum levels of type I and III procollagen fragments in Paget’s disease of bone. J. Clin. Endo. Metab. 58, 110, 1984.CrossRefGoogle Scholar
  27. 27.
    Singer, F.R. and Ahrne-Collier, I: Salmon calcitonin therapy: antibodies and clinical resistance in patients with Paget’s disease of bone In, Proc. Conference on Molecular Endocrinology, Endocrinology’77. Eds: Maclntyre, I. and Szelke, M., Elsevier./North Biomedical Press, Amsterdam, New York, 1977, pp 207–213.Google Scholar
  28. 28.
    Singer, F.R., Mills, B.G., Park, M.S., Takemura, S., and Teraskai, P.I. Increased HLA-DQW. Antigen pattern in Paget’s disease of bone. Clin. Res. 33, 547A, 1985.Google Scholar
  29. 29.
    Singer, F.R., Schiller, A., Pyle, E.B., and Krane, S.M.: Paget’s disease of bone. In, Metabolic Bone Disease, Vol. 2. Eds: Avioli, L. and Krane, S., Academic Press, New York, 1978, p. 492.Google Scholar
  30. 30.
    Siris, E.S., Jacobs, T.P., and Canfield, R.E.: Paget’s disease of bone. Bull. N.Y. Acad. Med. 56, 285, 1981.Google Scholar
  31. 31.
    Smith, M.L., Fogelman, I., Ralston, S., Boyce, B.F., and Boyle, I.T.: Correlation of skeletal uptake of 99m-Tc-diphosphonate and alkaline phosphatase before and after oral disphosphonate therapy in Paget’s disease. Metab. Bone Dis. Rel. Res. 5, 167, 1984.CrossRefGoogle Scholar
  32. 32.
    Taubman, M.B., Kammerman, S., and Goldberg, B.: Radioimmunoassay of procollagen in serum of patients with Paget’s disease of bone. Proc. Soc. Exp. Biol. Med. 152, 284, 1976.PubMedGoogle Scholar
  33. 33.
    Van Lente, R.: Alkaline and acid phosphatase determinations in bone disease. Orthop. Clin. N.A. 11, 437, 1979.Google Scholar
  34. 34.
    Vellenga, C., Pauwels, E.K., Bijvoet, O.L., Frijlink, W.B., Mulder, J.D., and Hermans, J.: Untreated Paget’s disease of bone studied by scintigraphy. Radiology 153, 799, 1984.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • J. R. Shapiro

There are no affiliations available

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