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Michael Additions

  • Manfred T. Reetz
Part of the Reactivity and Structure: Concepts in Organic Chemistry book series (REACTIVITY, volume 24)

Abstract

Although triisopropoxy- and tris(dialkylamino) titanium enolates as well as alkyl- and aryltitanium reagents RTiX3 (R = OCHMe2, Cl) generally react with, α β-unsaturated aldehydes and ketones in a 1,2 manner [1–3] (Chapter 3), titanium chemistry can be used to accomplish Michael additions in certain cases. A synthetically important example involves the TiCl4 induced 1,4-addition of allylsilanes to α, β-unsaturated ketones (HosomiSakurai reaction) [4, 5] which has been applied in numerous cases (e.g., 4→5) [4]. Since several reviews [5] have appeared, it will not be discussed here in great detail.

Keywords

Nitro Compound Michael Addition Tetra Butyl Proton Sponge Michael Acceptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Manfred T. Reetz
    • 1
  1. 1.Fachbereich Chemie der Universität MarburgMarburgGermany

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