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Brain Edema pp 550-554 | Cite as

Effects of Indomethacin on the Pathophysiology of Temporary Focal Ischemia

  • K. Aritake
  • M. Brock
Conference paper

Abstract

Interest has increased in the role of arachidonic acid metabolism in cerebral ischemia and associated brain edema. In the gerbil, reperfusion of the brain after brief ischemic episodes is followed by the occurrence of large amounts of arachidonic acid metabolites [3, 7]. It therefore appears likely that reestablishment of blood flow, that is, the sudden supply of oxygen to ischemic brain tissue rich in arachidonic acid, results in an explosive enhancement of arachidonic acid conversion via cyclo-oxygenase.

Key words

Brain edema temporary ischemia cerebral blood flow indomethacin arachidonic acid 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • K. Aritake
    • 1
  • M. Brock
  1. 1.Department of Neurosurgery, Universitätsklinikum SteglitzFree University of BerlinBerlin 45Germany

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