Effects of Indomethacin on the Pathophysiology of Temporary Focal Ischemia
Interest has increased in the role of arachidonic acid metabolism in cerebral ischemia and associated brain edema. In the gerbil, reperfusion of the brain after brief ischemic episodes is followed by the occurrence of large amounts of arachidonic acid metabolites [3, 7]. It therefore appears likely that reestablishment of blood flow, that is, the sudden supply of oxygen to ischemic brain tissue rich in arachidonic acid, results in an explosive enhancement of arachidonic acid conversion via cyclo-oxygenase.
Key wordsBrain edema temporary ischemia cerebral blood flow indomethacin arachidonic acid
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