Brain Edema pp 344-353 | Cite as

Na+-K+-Activated Adenosine Triphosphatase Activity and Lipoperoxide Metabolites in Microvessels and Parenchymas of the Ischemic Brain

  • Y. Fujita
  • T. Shingu
  • M. Kurihara
  • H. Miyake
  • T. Kono
  • K. Mori


To maintain electrolyte homeostasis in the brain, membrane-bound (Na + K)-ATPase is localized at the membranes of capillary endothelium, choroid plexus epithelium, and brain parenchymal cells (glia and neurons). This enzyme is susceptible to ischemic insults [16], and the different susceptibility of each membrane-bound (Na + K)ATPase to ischemic insults may modify the features of brain edema (cytotoxic or vasogenic edema). The precise mechanism of this susceptibility and inactivation of this enzyme in the ischemia is poorly understood.

Key words

Ischemic brain edema Na+-K+-ATPase P-NPPase lipoperoxide prostaglandin 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Y. Fujita
    • 1
  • T. Shingu
  • M. Kurihara
  • H. Miyake
  • T. Kono
  • K. Mori
  1. 1.Department of NeurosurgeryKurashiki Central HospitalJapan

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