Brain Edema pp 245-249 | Cite as

Restriction of Cellular Swelling and Spontaneous Increase in the Osmolality of the Intracellular Fluid in a Simplistic Cell Model

  • M. Tomita
  • F. Gotoh
  • M. Kobari
  • T. Shinohara
  • Y. Terayama
  • B. Mihara
  • P. Turcani
Conference paper

Abstract

As a possible mechanism of the cellular swelling in cytotoxic edema, fluid shift from the extracellular compartment to the intracellular compartment due to isothermal, isobaric, and iso-osmotic osmosis was demonstrated experimentally by Tomita [3] in a simplistic cell model. This process would proceed iso-osmotically if the cell membrane were sufficiently flaccid not to impede the cellular swelling. However, cellular swelling in situ is restricted by the tension developed by the surrounding tissue of the glial layers, the constraint of the pia and dura, and finally the rigidity of the closed calvarium.

Key words

Cytotoxic edema cellular swelling iso-osmotic osmosis hyperosmotic osmosis osmolality 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Katzman R, Pappius HM (1973) Brain electrolytes and fluid metabolism. Williams and Wilkins, Baltimore, pp 6–8Google Scholar
  2. 2.
    Leaf A (1956) On the mechanism of fluid exchange of tissues in vitro. Biochem J 62:241–248PubMedGoogle Scholar
  3. 3.
    Tomita M (1985) Mechanism of cytotoxic edema. In: Mchedlishvili GI, et al. (eds) Pathophysiological mechanisms of brain edema development. Akadémiai Kiadó, Budapest (in press)Google Scholar
  4. 4.
    Tomita M, Gotoh F, Sato T, Yamamoto M, Amano T, Tanahashi N (1979) Determination of the osmotic potential for swelling of cat brain in vitro. Exp Neurol 65:66–77PubMedCrossRefGoogle Scholar
  5. 5.
    Zimmermann Z, Hossmann K-A (1975) Resuscitation of the monkey brain after one hour’s complete ischemia. II: Brain water and electrolytes. Brain Res 85:1–11PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • M. Tomita
    • 1
  • F. Gotoh
  • M. Kobari
  • T. Shinohara
  • Y. Terayama
  • B. Mihara
  • P. Turcani
  1. 1.Department of Neurology, School of MedicineKeio UniversityShinjaku-ku, Tokyo 160Japan

Personalised recommendations